Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Azra Hadi Ligon, Ph.D.

Associate Professor of Pathology, Harvard Medical School
Director, BWH Clinical Cytogenetics Laboratory
Cytogeneticist, DFCI/BWH Center for Molecular Oncologic Pathology Director, HMS ABMGG Fellowship in Clinical Cytogenetics
Cytogeneticist, DFCI/BWH Center for Molecular Oncologic Pathology
Academic Activities:

Office
75 Francis Street
Shapiro Bldg, Rm. 5048
Boston,MA 02115
Email1: aligon@partners.org
Education and Training:

Graduate School - : MD Anderson Cancer Center/University of Texas Health Science Center Ph.D.
Fellowship - : Baylor College of Medicine

Clinical Specialties:
  • Cytogenetics
Research Interests: Publication:
  1. Cryan JB, Haidar S, Ramkissoon LA, Bi WL, Knoff D, Abedalthagafi M, Wen P, Reardon D, Dunn IF, Folkerth RD, Santagata S, Lindeman NI, Ligon AH, Beroukhim R, Hornick J, Alexander B, Ligon KL, Ramkissoon SH. Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. In press, OncoTarget.
  2. Francis JM, Zhang C-Z, Maire CL, Jung J, Manzo VE, Adalsteinsson VA, Homer H, Haidar S, Blumenstiel B, Pedamallu CS, Ligon AH, Love JC, Meyerson M, Ligon KL. EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing. Cancer Discovery 2014 June 3. Epub ahead of print.
  3. Pettersson A, Graff RE, Bauer SR, Pitt MJ, Lis RT, Stack EC, Martin NE, Kunz L, Penney KL, Ligon AH, Suppan C, Flavin R, Sesso HD, Rider JR, Sweeney C, Stampfer MJ, Fiorentino M, Kantoff PW, Sanda MG, Giovannucci EL, Ding EL, Loda M, Mucci LA. The TMPRSS2:ERG Rearrangement, ERG Expression, and Prostate Cancer Outcomes: A Cohort Study and Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2012 Sep;21(9):1497-509
  4. Cho Y-J, Tsherniak A, Tamayo P, Santagata S, Ligon AH, Greulich H, Luz J, Beroukhim R, Getz G, Amani V, Goumnerova L, Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A, Haberler C, Delattre O, Kool M, Ligon KL, Meyerson M, Mesirov JP, Pomeroy SL. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol, 2010. Dec 6. Epub ahead of print.
  5. Badalian-Very G, Vergilio JA, Degar BA, Brandner B, Calicchio M, Kuo FC, Longtine JA, Ligon AH, Kehoe SM, Macconaill LE, Garraway LA, Hahn WC, Meyerson ML, Fleming MD, and Rollins BJ. High prevalence BRAF mutations in Langerhans cell histiocytosis. Blood. 2010 Sep 16;116(11):1919-23.
  6. Craig JM, Vena N, Ramkissoon S, Idbaih A, Fouse SD, Ozek M, Sav A, Hill DA, Margraf LR, Eberhart CG, Kieran MW, Norden AD, Wen PY, Loda M, Santagata S, Ligon KL, Ligon AH. DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues. PLoS One. 2012;7(6):e38881.
  7. Glass LRD, Canoll P, Lignelli A, Ligon AH, Kazim M. Optic nerve glioma: case series with review of clinical, radiologic, molecular and histopathologic characteristics. Ophthal Plast and Reconstr Surg 2014. Apr 23. Epub ahead of print.
  8. Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, Nikhbakht H, Gerges N, Fiset P-O, Bechet D, Faury D, De Jay N, Jones DTW, Sturm D, Johann P, Tomita T, Goldman S, Nagib M, Bendel A, Goumnerova L, Bowers D, Leonard JR, Rubin JB, Alden T, Browd S, Geyer JR, Jallo G, Cohen K, Gupta N, Prados MD, Carret A-S, Ellezam B, Klekner A, Bognar L, Hauser P, Garami M, Myseros J, Ligon AH, Albrecht S, Pfister SM, Ligon KL, Majewski J, Jabado N, Kieran MW. Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. Nat Genet. 2014 May;46(5):462-6.
  9. Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles CD, Santagata S, Chan JA, Kieran MW, Ligon KL. Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Mol Diagn. 2011 Nov;13(6):669-77.
  10. Benedettini E, Sholl LM, Peyton M, Reilly J, Ware C, Davis L, Vena N, Bailey D, Yeap BY, Fiorentino M, Ligon AH, Pan BS, Richon V, Minna JD, Gazdar AF, Draetta G, Bosari S, Chirieac LR, Lutterbach B, Loda M. Met Activation in Non-Small Cell Lung Cancer Is Associated with de Novo Resistance to EGFR Inhibitors and the Development of Brain Metastasis. Am J Pathol. 2010 Jul;177(1):415-23.
  11. Flores LM, Kindelberger, Ligon AH, Capelletti M, Fiorentino M, Loda M, Cibas ES, Janne PA and Krop IE. Improved the yield of circulating tumor cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer. Br J Cancer, 2010 May 11:102(10):1495-502.
  12. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Jul 31;43(9):869-74.
  13. Riester M, Werner L, Bellmunt J, Selvarajah S, Guancial EA, Weir BA, Stack EC, Park RS, O’Brien R, Schutz FA, Choueiri TK, Signoretti S, Lloreta J, Marchionni L, Gallardo E, Rojo F, Garcia DI, Checkaluk Y, Kwiatowski D, Bochner BH, Hahn WC, Ligon AH, Barletta JA, Loda M, Berman DM, Kantoff PW, Rosenberg J, Michor F. Integrative analysis of 1q23.3 copy number gain in metastatic urothelial carcinoma. Clin Cancer Res. 2014 Apr 1;20(7):1873-83.
  14. Karst A, Jones P, Vena N, Ligon AH, Liu J, Hirsch M, Bowtell D, Etemadmoghadam D, Drapkin R. Cyclin E deregulation occurs early in fallopian tube-derived high-grade serous ovarian cancer and promotes secretory cell transformation. Cancer Res. 2014 Feb 15;74(4):1141-52.
  15. Dias-Santagata D, Lam Q, Vernovsky K, Vena N, Lennerz JK, Borger DR, Batchelor TT, Ligon KL, Iafrate AJ, Ligon AH, Louis DN, Santagata S. BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PLoS One. 2011 Mar 29;6(3):e17948.
  16. Priolo C, Agostini M, Vena N, Protopopov A, Ligon AH, Fiorentino M, Farsetti A, Pontecorvi A, Sicinska E, Loda M. Establishment and genomic characterization of mouse xenografts of human primary prostate tumors. Am J Pathol. 2010 Apr;176(4):1901-13.
  17. Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, McHenry K, Pinchback R, Ligon AH, et al. The landscape of copy number alterations across multiple human cancers. Nature. 2010: Feb 18;463(7283):899-905.
  18. Ligon AH, Morton CC, Bieber FR, Fletcher JA, Giersch AB, Kantarci S, Leach N, Lee C, Sandstrom M, Weremowicz S, Xiao S, Dal Cin P., Reporting of diagnostic cytogenetic results. Curr Protoc Hum Genet. 2010 Oct;Appendix 1:1D.1-23
  19. Selvarajah S, Saumyadipta P, Chen E, Ligon AH, Nielsen GP, Dranoff G, Loda M and Flavin R. High resolution aCGH and gene expression profiling of alveolar soft part sarcoma. Clin Cancer Res, 2014 Mar 15; 20(6);1521-30.
  20. Wen PY, Chang SM, Lamborn KR, Kuh JG, Norden AD, Cloughesy TF, Robins HI, Lieberman FS, Gilbert MR, Mehta MP, Drappatz J, Groves M, Santagata S, Ligon AH, Yung WKA, Wright JJ, Dancey J, Aldape KD, Prados MD, Ligon KL. Phase I/II study of Erlotinib and Temsirolimus for patients with recurrent malignant glioma: North American Brain Tumor Consortium (NABTC) Trial 04-02. Neuro Oncol 2014. Apr;16(4)567-78.
  21. Yusupov R, Roberts A, Lacro RV, Sandstrom M, Ligon AH. Potocki-Lupski Syndrome: An inherited dup(17)(p11.2p11.2) with hypoplastic left heart anomaly. Am J Med Genet, 2011 Feb;155A(2):367-71
  22. Wagner AJ, Malinowska-Kolodziej I, Morgan JA, Qin W, Fletcher CDM, Vena N, Ligon AH, Antonescu CR, Ramaiya NH, Demetri GD, Kwiatkowski DJ, Maki RG. mTORC1 activation and clinical utility of sirolimus in patients with malignant PEComa. J Clin Oncol. 2010: Feb 10;28(5):835-40.
  23. Clauss A, Ng V, Liu J, Piao H, Russo M, Vena N, Sheng Q, Hirsch M, Bonome T, Matulonis U, Ligon AH, Birrer MJ, Drapkin R. Overexpression of Elafin in ovarian carcinoma is driven by genomic gains and activation of the NF-kB pathway and is associated with poor overall survival. Neoplasia. 2010: Feb;12(2):161-72.
  24. Levanon K, Sapoznik S, Bahar-Shany K, Brand H, Shapira-Frommer R, Korach J, Hirsch MS, Roh MH, Miron A, Liu JF, Vena N, Ligon AH, Fotheringham S, Bailey D, Flavin RJ, Birrer MJ, Drapkin RI. FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis. Oncogene. 2013 Sep 30;doi:10.1038/onc.2013.394.
  25. Rodriguez FJ, Ligon AH, Horkayne-Szakaly I, Rushing EJ, Ligon KL, Vena N, Garcia DI, Cameron JD, Eberhart CG. BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper. J Neuropathol Exp Neurol. 2012 Sep;71(9):789-94.
  26. Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McIenna A, Lawrence M, Bergthold G, Brastianos PK, Tabak B, Ducar MD, van Hummelen P, MacConaill LE, Cho Y-J, Taha H, Mahmoud M, Bowers DC, Margarf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating arrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8188-93.
  27. Dal Cin P and Ligon AH. Tumors of the Urinary Tract, in Cancer Cytogenetics, Heim S and Mitelman F, eds. 3rd Edition. Wiley-Blackwell, Hoboken, NJ; 2009; Chapter 14.
  28. Snuderl M, Eichler AF, Ligon KL, Vu Q, Silver M, Betensky RA, Ligon AH, Wen PY, Louis DN, Iafrate AJ. Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss. Clin Cancer Res. 2009: Oct 15;15(20):6430-7.
  29. Nucera C, Eeckhoute J, Finn S, Carroll JS, Ligon AH, Priolo C, Fadda G, Toner M, Sheils O. Attard M, Pontecorvi A, Nose V, Loda M, Brown M. FOXA1 is a potential oncogene in anaplastic thyroid carcinoma. Clin Cancer Res. 2009: Jun 1;15(11):3680-9.
  30. Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino A, Chheda M, Tamayo P, Finn S, Shrestha Y, Boehm JS, Jain S, Bojarski E, Barretina J, Chan JA, Baselga J, Tabernero J, Root DE, Fuchs C, Loda M, Shivdasani RA, Meyerson M, Hahn WC. CDK8 is a colorectal cancer oncogene that regulates b-catenin. Nature, 2008: 455(7212):547-51.
  31. Yeh I-T, Lenci RE, Buddavarapu K, Ligon AH, Leteurtre E, Do Cao C, Cardot-Bauters C, Pigny P, Dahia PLM. A germline mutation of KIF1Bb on 1p36 segregates with neural and nonneural tumors in a cancer-prone family. Human Genetics, 2008:124(3):279-85.
  32. Chiang DY, Villanueva A, Hoshida Y, Peix J, Newell P, Minguez B, Donovan DJ, Cozza A, Sole M, Tovar V, Alsinet C, Ramos A, Barretina J, Roayai S, Schwartz M, Bruix J, Mazzaferro V, Najfeld V, Thing SW, Ligon AH, Waxman S, Friedman S, Sellers WR, Meyerson M, Llovet JM. Focal gains of vascular endothelial growth factor A and molecular classification of hepatocellular carcinoma. Cancer Research, 2008:68(16):6779-88.
  33. Schuller U, Heine V, Mao J, Kho AT, Dillon AK, Han Y-G, Huillard E, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, Ligon KL. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form medulloblastoma. Cancer Cell, 2008:14(2):123-134.
  34. Kulkarni S, Nagarajan P, Wall J, Donovan D, Donell RL, Ligon AH, Venkatachalam S, Quade BJ: Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis. Am J Med Genet, 2008:146A(9):1117-27.
  35. Higgins AW, Alkuraya FS, Bosco AF, Brown KK, Bruns GAP, Donovan DJ, Eisenman R, Fan Y, Farra CG, Ferguson HL, Gusella JF, Harris DJ, Herrick SR, Kelly C, Kim H-G, Kishikawa S, Korf BR, Kulkarni S, Lally E, Leach NT, Lemyre E, Lewis J, Ligon AH, Lu W, Maas RL, MacDonald ME, Moore SDP, Peters RE, Quade BJ, Quintero-Rivera F, Saadi I, Shen Y, Shendure J, Williamson RE, Morton CC. Characterization of apparently balanced chromosomal rearrangements from the Developmental Genome Anatomy Project. Am J Hum Genet. 2008:82(3):712-22.
  36. Hodge JC, Lawson-Yuen A, Stoler JM, Ligon AH. Molecular studies of segmental aneusomy: FISHing for the atypical cry in del(5)(p15.3). Cytogenet Genome Res. 2007:119(1-2):15-20.
  37. *Lu W, *Quintero-Rivera F, Fan Y, Alkuraya F, Donovan DJ, Xi Q, Turbe-Doan A, Li Q, Campbell CG, Shanske AL, Sherr E, Ahmad A, Peters R, Rilliet B, Parvex P, Bassuk AG, Harris DJ, Ferguson H, Kelly C, Walsh C, Gronostajski RM, Devriendt K, Higgins AW, Ligon AH, Quade BJ, Morton CC, Gusella JF, Maas RL. NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects. PLoS Genetics 2007:3(5)830-843. (*Contributed equally)
  38. Leach NT, Sun Y, Michaud S, Zheng Y, Ligon KL, Ligon AH, Sander T, Korf BR, Lu W, Harris DJ, Gusella JF, Maas RL, Quade BJ, Cole AJ, Kelz MB, Morton CC. Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. Am J Hum Genet 2007; (80)792-799.
  39. Quintero-Rivera F, Chan A, Donovan D, Gusella JF, Ligon AH. Disruption of a Synaptotagmin (SYT14) associated with neurodevelopmental abnormalities. Am J Med Genet A. 2007; Mar 15;143(6):558-63.
  40. Kim H-G, Higgins A, Herrick SR, Nicholson L, Kutsche K, Ligon AH, Harris DJ, MacDonald ME, Bruns GAP, Morton CC, Quade BJ, Gusella JF. Candidate loci for Zimmermann-Laband syndrome at 3p14.3. Am J Med Genet A 2007; Jan 15;143(2):107-11.
  41. Ligon AH, DeAngelo DJ, Atkins L, Dal Cin P. Isochromosome of a deleted 20q may be a relatively common abnormality in myeloid malignancies. Cancer Genet Cytogenet 2005; 162:89-91.
  42. *Ligon AH, *Moore SD, Parisi MA, Mealiffe ME, Harris DJ, Ferguson HL, Quade BJ, Morton CC. Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. Am J Hum Genet 2005; 76(2):340-8. (*Contributed equally)
  43. Christacos NC, Ligon AH, Morton CC. Genetics of uterine leiomyomata. In: Sciarra JJ, (editor) Gynecology and Obstetrics. Chicago: Lippincott-Raven Press; 2004; 5,Chapter 96.
  44. Ligon AH. Educational Insight: Telomeres and Telomerase. Atlas of Genetics and Cytogenetics in Oncology and Haematology. Posted: June 2004.
  45. NULLLigon AH, Morton CC, Bieber FR, Fletcher JA, Giersch AB, Lee C, Sandstrom M, Weremowicz S, Xiao S, Dal Cin P. Reporting of Diagnostic Cytogenetic Results. In: Drapoli NC, Haines JL, Korf BR, Morton CC, Seidman CE, Seidman JG, Smith DR, editors. Current Protocols in Human Genetics. Wiley & Sons, Rockville, MD; 2004, Supplement 43, A.1D.1 - A.1D.27.
  46. Gross KL, Neskey DM, Manchanda N, Weremowicz S, Kleinman M, Nowak RA, Ligon AH, Rogalla P, Drechsler K, Bullerdiek J, Morton CC: HMGA2 expression in uterine leiomyomata and myometrium: Quantitive analysis ans tissue culture studies. Genes Chrom Cancer 2003;38(1):68-79.
  47. Scherer SW, Cheung J, MacDonald JR, Osborne LP, Nakabayaski K, Herbrick J-A, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulous CC, Choufani S, Kwasnicka D, Zheng XH, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirtpatrick SJ, Rahman N, Friedman JM, Heng HHQ, Pelicci PG, Lococo F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GAP, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim H-G, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJT, Grzeschik K-H, Teebi Ah, Minassian BA, Kere J, Armengol L, Pugana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui L-C. Human chromosome 7: DNA sequence and biology. Science 2003;300(5620):767-72.
  48. Ligon AH, Scott IC, Takahara K, Greenspan DS, Morton CC. PCOLCE deletion and expression analyses in uterine leiomyomata. Cancer Genet Cytogenet 2002;137(2):133-7.
  49. Cheung VG, Nowak N, Jang W, Kirsch IR, Zhao S, Chen XN, Furey TS, Kim UJ, Kuo WL, Oliver M, Conroy J, Kasprzyk A, Massa H, Yonescu R, Sait S, Thoreen C, Snijders A, Lemyre E, Bailey JA, Bruzel A, Burrill WD, Clegg SM, Collins S, Dhami P, Friedman C, Hans CS, Herrick S, Lee J, Ligon AH, et al. Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature 2001; 409 (6822):953-958.
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<Wednesday, September 03, 2014>
8:00 AM

Autopsy suite
8:00 AM

Abrams conference room
1:00 PM
Dr. Bradley Quade
Cotran Conference Center
4:00 PM

Cytology conference room
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