Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Azra Hadi Ligon, Ph.D.

   Assistant Professor of Pathology
Academic Activities:
Office
75 Francis Street
Shapiro Bldg, Rm. 5048
Boston,MA 02115
Email1: aligon@partners.org
Education and Training:

Graduate School - : University of Texas Health Science Center Ph.D.

Clinical Specialties:
  • Cytogenetics
Research Interests: Publication:
  1. Cheung VG, Nowak N, Jang W, Kirsch IR, Zhao S, Chen XN, Furey TS, Kim UJ, Kuo WL, Oliver M, Conroy J, Kasprzyk A, Massa H, Yonescu R, Sait S, Thoreen C, Snijders A, Lemyre E, Bailey JA, Bruzel A, Burrill WD, Clegg SM, Collins S, Dhami P, Friedman C, Hans CS, Herrick S, Lee J, Ligon AH, et al. Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature 2001; 409 (6822):953-958.
  2. Ligon AH, Scott IC, Takahara K, Greenspan DS, Morton CC. PCOLCE deletion and expression analyses in uterine leiomyomata. Cancer Genet Cytogenet 2002;137(2):133-7.
  3. Scherer SW, Cheung J, MacDonald JR, Osborne LP, Nakabayaski K, Herbrick J-A, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulous CC, Choufani S, Kwasnicka D, Zheng XH, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirtpatrick SJ, Rahman N, Friedman JM, Heng HHQ, Pelicci PG, Lococo F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GAP, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim H-G, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJT, Grzeschik K-H, Teebi Ah, Minassian BA, Kere J, Armengol L, Pugana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui L-C. Human chromosome 7: DNA sequence and biology. Science 2003;300(5620):767-72.
  4. Gross KL, Neskey DM, Manchanda N, Weremowicz S, Kleinman M, Nowak RA, Ligon AH, Rogalla P, Drechsler K, Bullerdiek J, Morton CC: HMGA2 expression in uterine leiomyomata and myometrium: Quantitive analysis ans tissue culture studies. Genes Chrom Cancer 2003;38(1):68-79.
  5. NULLLigon AH, Morton CC, Bieber FR, Fletcher JA, Giersch AB, Lee C, Sandstrom M, Weremowicz S, Xiao S, Dal Cin P. Reporting of Diagnostic Cytogenetic Results. In: Drapoli NC, Haines JL, Korf BR, Morton CC, Seidman CE, Seidman JG, Smith DR, editors. Current Protocols in Human Genetics. Wiley & Sons, Rockville, MD; 2004, Supplement 43, A.1D.1 - A.1D.27.
  6. Ligon AH. Educational Insight: Telomeres and Telomerase. Atlas of Genetics and Cytogenetics in Oncology and Haematology. Posted: June 2004.
  7. Christacos NC, Ligon AH, Morton CC. Genetics of uterine leiomyomata. In: Sciarra JJ, (editor) Gynecology and Obstetrics. Chicago: Lippincott-Raven Press; 2004; 5,Chapter 96.
  8. *Ligon AH, *Moore SD, Parisi MA, Mealiffe ME, Harris DJ, Ferguson HL, Quade BJ, Morton CC. Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. Am J Hum Genet 2005; 76(2):340-8. (*Contributed equally)
  9. Ligon AH, DeAngelo DJ, Atkins L, Dal Cin P. Isochromosome of a deleted 20q may be a relatively common abnormality in myeloid malignancies. Cancer Genet Cytogenet 2005; 162:89-91.
  10. Kim H-G, Higgins A, Herrick SR, Nicholson L, Kutsche K, Ligon AH, Harris DJ, MacDonald ME, Bruns GAP, Morton CC, Quade BJ, Gusella JF. Candidate loci for Zimmermann-Laband syndrome at 3p14.3. Am J Med Genet A 2007; Jan 15;143(2):107-11.
  11. Quintero-Rivera F, Chan A, Donovan D, Gusella JF, Ligon AH. Disruption of a Synaptotagmin (SYT14) associated with neurodevelopmental abnormalities. Am J Med Genet A. 2007; Mar 15;143(6):558-63.
  12. Leach NT, Sun Y, Michaud S, Zheng Y, Ligon KL, Ligon AH, Sander T, Korf BR, Lu W, Harris DJ, Gusella JF, Maas RL, Quade BJ, Cole AJ, Kelz MB, Morton CC. Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. Am J Hum Genet 2007; (80)792-799.
  13. *Lu W, *Quintero-Rivera F, Fan Y, Alkuraya F, Donovan DJ, Xi Q, Turbe-Doan A, Li Q, Campbell CG, Shanske AL, Sherr E, Ahmad A, Peters R, Rilliet B, Parvex P, Bassuk AG, Harris DJ, Ferguson H, Kelly C, Walsh C, Gronostajski RM, Devriendt K, Higgins AW, Ligon AH, Quade BJ, Morton CC, Gusella JF, Maas RL. NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects. PLoS Genetics 2007:3(5)830-843. (*Contributed equally)
  14. Hodge JC, Lawson-Yuen A, Stoler JM, Ligon AH. Molecular studies of segmental aneusomy: FISHing for the atypical cry in del(5)(p15.3). Cytogenet and Genome Res, in press
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