Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Andrew Harry Lichtman, M.D.,Ph.D.

Professor of Pathology, Harvard Medical School

Academic Activities:
My laboratory studies the role of inflammation and immune responses in cardiovascular disease, with a focus on T cell mediated pathology. Major current projects focus on T cell-endothelial interactions in regulating T cell subset migration into tissues, and the influence of co-stimulatory pathways and regulatory T cells in atherosclerotic disease. We employ genetically modified mouse models of atherosclerosis and myocardial inflammation, functional assays of human T cells and antigen presenting cells in vitro, imaging of atherosclerotic lesions by confocal microscopy, in vitro flow chamber and intravital microscopic examination of leukocyte-endothelial interactions, and various analyses of gene and protein expression.
77 Avenue Louis Pasteur
HNRB 751n
Boston,MA 02115
Education and Training:

Medical School - : University of Rochester School of Medicine and Dentistry M.D.,Ph.D.
Residency 7/1/1982 - 6/30/1984 : Brigham and Women's Hospital
Professional Position 1984 - 1987 : Brigham and Women's Hospital

Clinical Specialties:
  • Autopsy Pathology
Research Interests:
  • Immunology
  1. Grabie N, Delfs MW, Westrich J, Love VA, Stavrakis G, Ahmad F, Seidman CE, Seidman JG, and Lichtman AH. IL-12 is required for differentiation of pathogenic CD8+ T effectors that cause myocarditis. Journal of Clinical Investigation. 2003; 111: 671-680.
  2. Buono C, Come CE, Stavrakis G, Maguire G, Connelly PW, and Lichtman AH. Influence of interferon-g on extent and phenotype of diet-induced atherosclerosis in the LDLR deficient mouse. Arteriosclerosis, Thrombosis and Vascular Biology. 2003; 23:454-460.
  3. Grabie N, Hsieh DT, Buono C, Westrich JR, Allen JA, Pang H, Stavrakis G, Lichtman AH. Neutrophils sustain pathogenic CD8+ T cell responses in the heart. American Journal of Pathology. 2003, 163:2413-2420.
  4. Buono C, Pang H, Uchida Y, Libby P, Sharpe A, and Lichtman AH. B7-1/B7-2 co-stimulation regulates plaque antigen-specific T cell responses and atherogenesis in LDLR-deficient mice. Circulation. 2004, 109:2009-2015.
  5. Buono C, Pang H, Stavrakis G, Witztum J, Glimcher L, and Lichtman AH. T-bet deficiency reduces atherosclerosis and alters plaque antigen specific immune responses. Proceedings of the National Academy of Science, USA. 2005, 102:1596-1601.
  6. Taqueti VR, Grabie N, Colvin R, Pang H, Jarolim P, Luster A, Glimcher L, Lichtman AH. T-bet controls pathogenicity of cytotoxic T lymphocytes in the heart by separable effects on migration and effector activity. J Immunol. 2006; 177:5890-901.
  7. Gotsman I, Grabie N, Dacosta R, Sukhova G, Sharpe A, Lichtman AH. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway. J Clin Invest. 2007; 117:2974-82.
  8. Grabie N., Gotsman I, DaCosta R, Pang H; Stavrakis G, Butte MJ, Keir M, Freeman GJ, Sharpe AH, and Lichtman AH. Endothelial PD-L1 regulates CD8+ T cell mediated injury in the heart. Circulation. 2007. 116:2062-71.
  9. Packard RS, Maganto-Garcia E, Tabas I, Libby P, Lichtman AH. CD11c+ dendritic cells maintain antigen processing, presentation capabilities, and CD4+ T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Circ Res. 2008. 103:965-973.
  10. Bu D., Tarrio M, Grabie N, Zhang Y, Hiroyuki Y, Stavrakis S , Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, XAikawa M, García-Cardeña G, Lichtman AH. Statins reduce T cell inflammatory and pathogenic responses by inducing Kruppel-like factor 2 expression. J. Clin. Invest. 2010.120:1961–1970.
  11. Bu D, Tarrio M, Maganto-Garci E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GF, Sharpe AH, Lichtman AH. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011. 31:1100-7.
  12. Maganto-Garcia E, Tarrio M, Grabie N, Bu D, Lichtman AH. Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia. Circulation. 2011. 124:185-195.
  13. Maganto-Garcia E, Bu D, Tarrio M, Alcaide P, Newton G, Griffin G, Croce K, LuscinskasFW, Lichtman AH, Grabie N. Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment. J. Immunol. 2011. In Press.
<March 2018>

<Saturday, March 24, 2018>
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