Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
Login Skip Navigation Links
  Skip Navigation Links
HomeExpand Home





Announcement

Submit new announcement
Andrew Harry Lichtman, M.D.,Ph.D.

Professor of Pathology, Harvard Medical School



Academic Activities:
My laboratory studies the role of inflammation and immune responses in cardiovascular disease, with a focus on T cell mediated pathology. Major current projects focus on T cell-endothelial interactions in regulating T cell subset migration into tissues, and the influence of co-stimulatory pathways and regulatory T cells in atherosclerotic disease. We employ genetically modified mouse models of atherosclerosis and myocardial inflammation, functional assays of human T cells and antigen presenting cells in vitro, imaging of atherosclerotic lesions by confocal microscopy, in vitro flow chamber and intravital microscopic examination of leukocyte-endothelial interactions, and various analyses of gene and protein expression.
Office
77 Avenue Louis Pasteur
HNRB 751n
Boston,MA 02115
Email1: alichtman@rics.bwh.harvard.edu
Education and Training:

Medical School - : University of Rochester School of Medicine and Dentistry M.D.,Ph.D.
Residency 7/1/1982 - 6/30/1984 : Brigham and Women's Hospital
Professional Position 1984 - 1987 : Brigham and Women's Hospital

Clinical Specialties:
  • Autopsy Pathology
Research Interests:
  • Immunology
Publication:
  1. Grabie N, Delfs MW, Westrich J, Love VA, Stavrakis G, Ahmad F, Seidman CE, Seidman JG, and Lichtman AH. IL-12 is required for differentiation of pathogenic CD8+ T effectors that cause myocarditis. Journal of Clinical Investigation. 2003; 111: 671-680.
  2. Buono C, Come CE, Stavrakis G, Maguire G, Connelly PW, and Lichtman AH. Influence of interferon-g on extent and phenotype of diet-induced atherosclerosis in the LDLR deficient mouse. Arteriosclerosis, Thrombosis and Vascular Biology. 2003; 23:454-460.
  3. Grabie N, Hsieh DT, Buono C, Westrich JR, Allen JA, Pang H, Stavrakis G, Lichtman AH. Neutrophils sustain pathogenic CD8+ T cell responses in the heart. American Journal of Pathology. 2003, 163:2413-2420.
  4. Buono C, Pang H, Uchida Y, Libby P, Sharpe A, and Lichtman AH. B7-1/B7-2 co-stimulation regulates plaque antigen-specific T cell responses and atherogenesis in LDLR-deficient mice. Circulation. 2004, 109:2009-2015.
  5. Buono C, Pang H, Stavrakis G, Witztum J, Glimcher L, and Lichtman AH. T-bet deficiency reduces atherosclerosis and alters plaque antigen specific immune responses. Proceedings of the National Academy of Science, USA. 2005, 102:1596-1601.
  6. Taqueti VR, Grabie N, Colvin R, Pang H, Jarolim P, Luster A, Glimcher L, Lichtman AH. T-bet controls pathogenicity of cytotoxic T lymphocytes in the heart by separable effects on migration and effector activity. J Immunol. 2006; 177:5890-901.
  7. Gotsman I, Grabie N, Dacosta R, Sukhova G, Sharpe A, Lichtman AH. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway. J Clin Invest. 2007; 117:2974-82.
  8. Grabie N., Gotsman I, DaCosta R, Pang H; Stavrakis G, Butte MJ, Keir M, Freeman GJ, Sharpe AH, and Lichtman AH. Endothelial PD-L1 regulates CD8+ T cell mediated injury in the heart. Circulation. 2007. 116:2062-71.
  9. Packard RS, Maganto-Garcia E, Tabas I, Libby P, Lichtman AH. CD11c+ dendritic cells maintain antigen processing, presentation capabilities, and CD4+ T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Circ Res. 2008. 103:965-973.
  10. Bu D., Tarrio M, Grabie N, Zhang Y, Hiroyuki Y, Stavrakis S , Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, XAikawa M, García-Cardeña G, Lichtman AH. Statins reduce T cell inflammatory and pathogenic responses by inducing Kruppel-like factor 2 expression. J. Clin. Invest. 2010.120:1961–1970.
  11. Bu D, Tarrio M, Maganto-Garci E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GF, Sharpe AH, Lichtman AH. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011. 31:1100-7.
  12. Maganto-Garcia E, Tarrio M, Grabie N, Bu D, Lichtman AH. Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia. Circulation. 2011. 124:185-195.
  13. Maganto-Garcia E, Bu D, Tarrio M, Alcaide P, Newton G, Griffin G, Croce K, LuscinskasFW, Lichtman AH, Grabie N. Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment. J. Immunol. 2011. In Press.
<December 2017>
SuMoTuWeThFrSa
262728293012
3456789
10111213141516
17181920212223
24252627282930
31123456


<Friday, December 15, 2017>
8:00 AM
Dr. Eleanor Russell-Goldman, Dr. Kristine Wong
Cotran Conference Center
9:15 AM

Autopsy suite
12:00 PM

GYN 14-headed scope
1:00 PM
Dr. Christopher Fletcher
Cotran Conference Center
Copyright 2008 - 2017, BWH Pathology, All rights reserved.