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  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Arlene Helen Sharpe, M.D.,Ph.D.

Professor, Harvard Medical School



Academic Activities:

Education and Training:

Medical School - : Harvard Medical School M.D.
Graduate School - : Harvard University Graduate School of Arts And Sciences Ph.D.

Clinical Specialties: Research Interests:
  • Immunology
  • Mouse models
Publication:
  1. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995; 3:541-547.
  2. Chen AI, McAdam AJ, Buhlmann JE, Scott S, Lupher Jr. ML, Greenfield EA, Baum PR, Fanslow WC, Calderhead DM, Freeman GJ, Sharpe AH. Ox40 ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity 1999; 11:689-698.
  3. Latchman T, Wood CR, Chernova T, Chaudhard D, Borde M, Chernove I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LA, Carreno BM, Malenkovich N, Nishimura H, Honjo T, Freeman GJ*, Sharpe AH* (*co-senior authors). PD-L2 a B7 homologue, is a second ligand for PD-1 and inhibits T cell activation. Nature Immunology 2001; 2:261-268.
  4. Greenwald RJ, Boussiotis VA, Lohrsbach RB, Abbas AK, Sharpe AH. CTLA-4 regulates induction of anergy in vivo. Immunity 2001; 145-155.
  5. Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH. B7-dependent T cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest 2001; 107:881-887.
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