Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Christopher D.M. Fletcher, M.D.

Professor of Pathology, Harvard Medical School
Director of Surgical Pathology
Chief of Onco-Pathology, DFCI

Academic Activities:
Soft Tissue Tumors/Sarcomas
Office
75 Francis Street
AL3-101 Amory Building
Boston,MA 02115
Email1: cfletcher@partners.org
Education and Training:

Medical School - : University of London M.D.
Medical School - : United Medical and Dental Schools of Guy's and Saint Thomas' Hospitals M.B.B.S.
Internship 8/1/81 - 1/31/82 : Queen Mary's Hospital
Internship 2/1/82 - 7/31/82 : Kingston General Hospital
Residency 8/1/82 - 7/31/85 : St Thomas's Hospital, London, UK
Fellowship 8/1/85 - 7/31/89 : St. Thomas's Hospital, London, UK

Clinical Specialties:
  • Anatomic Pathology
  • Soft tissue and bone Pathology
  • Molecular Genetics
  • Hematopathology
Research Interests:
  • Sarcoma
  • Marker identification
Publication:
  1. Guillou L, Wadden C, Coindre JM, Krausz T, Fletcher CDM. Proximal-type epithelioid sarcoma: a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical and ultrastructural study of a series. Am J Surg Pathol 1997; 21:130-146.
  2. Granter SR, Badizadegan K, Fletcher CDM. Myofibromatosis in adults, glomangiopericytoma and myopericytoma: A spectrum of tumors showing perivascular myoid differentiation. Am J Surg Pathol 1998; 22:513-525.
  3. Fletcher CDM, Gustafson P, Rydholm A, Willen H, Akerman M. Clinicopathologic re-evaluation of 100 malignant fibrous histiocytomas: The prognostic relevance of subclassification. J Clin Oncol 2001; 19:3045-3050.
  4. McMenamin M, Fletcher CDM. Expanding the spectrum of malignant change in schwannomas: Epithelioid malignant change, epithelioid malignant nerve sheath tumor and epithelioid angiosarcoma: A study of 17 cases. Am J Surg Pathol 2001; 25:13-25.
  5. Kaddu S, McMenamin ME, Fletcher CDM. Atypical ('pseudosarcomatous') fibrous histiocytoma of the skin: clinicopathologic analysis of 59 cases with evidence of infrequent metastasis. Am J Surg Pathol 2002; 26:35-46.
  6. Fletcher CDM, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O'Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH, Weiss SW. Diagnosis of gastrointestinal stromal tumors: a concensus approach. Hum Pathol 2002; 33:459-465
  7. Hornick JL, Fletcher CDM. Myoepithelial tumours of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters. Am J Surg Pathol 2003; 27:1183-1196.
  8. Medeiros F, Corless CL, Duensing A, Hornick JL, Oliveira AM, Heinrich MC, Fletcher JA, Fletcher CDM. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am J Surg Pathol 2004; 28:889-894.
  9. Hornick JL, Fletcher CDM. Soft tissue perineurioma: analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol 2005; 29:845-858.
  10. Hornick JL, Fletcher CDM. Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol 2007; 31:329-340.
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