Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Heide Christine Patterson, M.D.

Instructor in Pathology, Harvard Medical School

Associate Pathologist, Laboratory for Molecular Medicine and Brigham and Women's Hospital
Visiting post-doctoral associate, Laboratory of Harvey Lodish
Academic Activities:
Mitochondrial Oxidative Stress Signaling
Whitehead Institute for Biomedical Research
9 Cambridge Center, Room 613
Cambridge,MA 02142
Education and Training:

Medical School - 1999 : Ludwig-Maximilians-University Munich, Germany M.D.
Medical School - 1999 : Johannes-Gutenberg-University Mainz, Germany D.MSc.
Residency 1999 - 2001 : LMU Munich/University of Freiburg, Germany
Fellowship 2001 - 2008 : Immune Disease Institute/Harvard Medical School
Residency 7/2008 - 9/2011 : Brigham and Women's Hospital
Fellowship 2011 - present : Whitehead Institute for Biomedical Research

Clinical Specialties: Research Interests:
  • Bioinformatics
  • Cancer
  • Cell metabolism
  • Signalling pathway
  • Receptor
  • Immunology
  • System biology
  • Genome wide analysis
  • Cell Biology
  1. Hattangadi SM, Martinez-Morilla S, Patterson HC, Burke KA, Avila Figueroa A, Venkatesan X, Wang J, Paulsen K, Huang CX, Gorlich D, Murata-Hori M, Lodish HF. Histones to the cytosol: Exportin 7 plays an important role in terminal erythroid nuclear maturation. Blood in press.
  2. Thai TH, Patterson HC, Pham DH, Kis-Toth K , Kaminski DA , Tsokos GC. Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Fas(lpr) mouse. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20194-9.
  3. Wang D, Hoeing S, Patterson HC, Ahmad UM, Rajewsky K, Fitzgerald KA, Golenbock DT. Inflammation in mice ectopically expressing PSTPIP1 with a PAPA Syndrome associated mutation. Journal of Biological Chemistry, 2013 Feb 15;288(7):4594-601.
  4. Sankaran VG, Ludwig LS, Sicinska E, Xu J, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes and Development, 2012 Sep 15;26(18):2075-87.
  5. Liu QQ, Yuan BB, Lo KA, Patterson HC, Sun Y, Lodish HF. Adiponectin regulates hepatic genes critical for glucose and lipid metabolism. Proceedings of the National Academy of Sciences, 2012 Sep 4;109(36):14568-73.
  6. Patterson HC, Kraus M, Wang D, Shahsafaei A, Henderson JM, Seagal J, Otipoby KL, Thai TH, Rajewsky K. Cytoplasmic Ig alpha Serine/Threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation. Journal of Immunology 2011, Sep;187(6):2853-8.
  7. Patterson HC, Sturtevant O, Schott D, Alyea EP, Onderdonk AB, Kao GS. Isolation of non-typhoidal Salmonella from a hematopoietic progenitor cell product. Transfusion Medicine 2010 Dec;20(6):424-5.
  8. Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K.Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes.Nat Immunol. 2008 Apr;9(4):405-14.
  9. Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Nat Immunol. 2008 Apr;9(4):405-14.
  10. Patterson HC, Kraus M, Kim YM, Ploegh H, Rajewsky K. The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. Immunity. 2006 Jul;25(1):55-65.
<June 2019>

<Monday, June 24, 2019>
8:00 AM

Cotran Conference Center
8:00 AM

Autopsy suite
9:00 AM

Clinical Lab conference room
3:00 PM

Dammin signout suite
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