Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Charles Lee, Ph.D.

   Associate Professor of Pathology

Director, Dana Farber / Harvard Cancer Center Cytogenetics Core
Academic Activities:
Structural genomic variation, Advanced molecular cytogenetics technologies, Cancer biomarkers, Disease association studies
Office
221 Longwood Avenue
EBRC 404A
Boston,MA 02115
Email1: clee@rics.bwh.harvard.edu 		Lab
221 Longwood Avenue
EBRC 404 / 412
Boston,MA 02115
Email1: clee@rics.bwh.harvard.edu
Education and Training:

Graduate School - : University of Alberta Ph.D.
Fellowship 1996 - 1998 : Cambridge University
Fellowship 1999 - 2002 : Harvard Medical School

Clinical Specialties:
  • Cytogenetics
Research Interests:
  • Genetic alteration
Publication:
  1. Lee C, Murray MF, Miron PM, Marsden D, Irons M, Wilkins-Haug LE, Morton CC. Clinical picture: Multicolor karyotyping. Lancet 2001; 357: 1240.
  2. Zhu C, Mills KD, Ferguson DO, Lee C, et al. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 2002; 109:811-821.
  3. Paw BH, Davidson AJ, Zhou Y, Li R, Pratt SJ, Lee C, et al. Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet 2003; 34: 59-64.
  4. Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW. Histone H2AX: A dosage dependent suppressor of oncogenic translocations and tumors. Cell 2003; 114: 359-370.
  5. Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C. Detection of large-scale variation in the human genome. Nat Genet 2004; 36: 949-51.
  6. Garraway LA, et. al. Integrative genomic analysis identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 2005; 436: 117-122.
  7. McCarroll SA, et. al. Common deletion variants in the human genome. Nat Genet 2006; 38: 86-92.
  8. Perry GH, Tchinda J, McGrath SD, Zhang J, Picker SR, Caceres AM, Iafrate AJ, Tyler-Smith C, Scherer SW, Eichler EE, Stone AC, Lee C. Hotspots for copy number variation in chimpanzees and humans. Proc Natl Acad Sci USA 2006; 103: 8006-8011.
  9. Redon R, et. al. Global variation in copy number in the human genome. Nature 2006; 444: 444-454.
  10. Khaja R, et al. Genome assembly comparison to identify structural variants in the human genome. Nat Genet 2006; 38: 1413-18.
  11. Stranger BE, et al. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 2007; 315: 848-853.
  12. Engelman, et al. MET amplification leads to gefitinib resistance via ERBB3 in EGFR mutant lung cancer. Science 2007; 316: 1039-1043.
  13. Freeman JL, et al. Definition of the zebrafish genome using flow cytometry and cytogenetic mapping. BMC Genomics 2007; 8: 195.
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