Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Frank Chuan Kuo, M.D.,Ph.D.

   Assistant Professor of Pathology

Director, Pathology IT
Academic Activities:

Office
75 Francis Street
AL-3-139 Amory Building
Boston,MA 02115
Email1: fkuo@partners.org
Education and Training:

Medical School - 1986 : National Taiwan University, Taiwan M.D.
Graduate School - : Rockefeller University Ph.D.
Internship 7/1/83 - 6/30/84 : National Taiwan University Hospital
Fellowship 7/1/90 - 12/31/90 : Rockefeller University
Residency/Fellowship 01/01/1991 - 3/30/1993 : Brigham and Women's Hospital
Fellowship 04/01/1993 - 10/31/1993 : Brigham and Women's Hospital
Professional Position 1994 - 1995 : Brigham and Women's Hospital

Clinical Specialties:
  • Anatomic Pathology
  • Hematopathology
  • Hematology
  • Molecular Diagnostics
  • Molecular Genetics
Research Interests:
  • Leukemia
  • Mutation
  • Gene expression profiling
  • Cancer
  • Tumor angiogenesis
  • Cancer
Publication:
  1. Tsai F-Y, Keller G, Kuo FC, Weiss M, Chen J-C, Alt F, Orkin SH. An early hematopoietic defect in mice lacking the transcription factor GATA-2. Nature 1994; 371:221-226.
  2. Tsai F-Y, Keller G, Kuo FC, Weiss M, Chen J-C, Alt F, Orkin SH. An early hematopoietic defect in mice lacking the transcription factor GATA-2. Nature 1994; 371:221-226
  3. Kuo FC, Sklar JL. Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers. J Exp Med 1997; 186:1547-1556
  4. Field S, Tsai F-Y, Kuo FC, Zubiaga AM, Kaelin WG, Livingston DM, Orkin SH, Greenberg ME. E2F1 functions in mice to promote apoptosis and suppress proliferation. Cell 1996; 85:549-561
  5. Field S, Tsai F-Y, Kuo FC, Zubiaga AM, Kaelin WG, Livingston DM, Orkin SH, Greenberg ME. E2F1 functions in mice to promote apoptosis and suppress proliferation. Cell 1996; 85:549-561.
  6. Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. Embo J 1997; 16:4374-4383.
  7. Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. Embo J 1997; 16:4374-4383
  8. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol & Cell Biol 1997; 17:6057-6067.
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