Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Justine A. Barletta, M.D.

Assistant Professor in Pathology, Harvard Medical School
Surgical pathologist with subspecialty interest in endocrine and genitourinary pathology


Academic Activities:
I conduct translational research in endocrine pathology. My current research interest in endocrine pathology is focused on thyroid malignancies. While the great majority of well-differentiated thyroid carcinomas behave indolently, a subset recurs and can result in patient demise. Additional risk stratification of thyroid carcinomas could spare some patients additional treatment that they might not require while identifying those that would benefit from more aggressive therapy. I am interested in combining molecular diagnostic approaches with those of more conventional histology to determine the optimal parameters for risk stratifying patients.
Office
75 Francis Street
AL-360G Amory Building
Boston,MA 02115
Email1: jbarletta@partners.org
Education and Training:

Medical School 08/15/2000 - 05/12/2005 : New York University School of Medicine M.D.
Internship 7/2002 - 6/2003 : University of California, San Francisco School of Medicine Post-sophomore pathology fellowship
Residency 2005 - 2009 : Brigham and Women's Hospital AP/CP
Fellowship 2009 - 2010 : Brigham and Women's Hospital Surgical Pathology Fellowship

Clinical Specialties:
  • Endocrine Pathology
  • Genitourinary Pathology
Research Interests: Publication:
  1. Lin CI, Barletta JA, Morris ZS, Donner DB, Whang EE, Jeong JW, Kimura JW, Kimura S, Moore FD Jr, Ruan DT. Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-kB activity. Surgery, 2011 Dec; 150(6):1295-302.
  2. Barletta JA, Bellizzi AM, Hornick JL. Immunohistochemical Staining of Thyroidectomy Specimens for PTEN Can Aid in the Identification of Patients with Cowden Syndrome. Am J Surg Pathol, 2011 Oct; 35 (10):1505-1511.
  3. Laury AR, Perets R, Piao H, Krane JF, Barletta JA, French, C, Chirieac LR, Lis R, Loda M, Hornick JL, Drapkin, Hirsch MS. A Comprehensive Analysis of PAX8 Expression in Human Epithelial Tumors. Am J Surg Pathol, 2011 Jun;35(6):816-26.
  4. Sholl LA, Barletta JA, Chirieac LR, Hornick JL. Sox2 Protein Expression is an Independent Poor Prognostic Indicator in Stage I Lung Adenocarcinomas. Am J Surg Pathol. 34(8): 1193-8.
  5. Spivey K, Banyard J, Solis L, Wistuba I, Barletta JA, Gandhi L, Feldman H, Rodig S, Chirieac LR, Zetter B. Collagen XXIII- a potential biomarker for the detection of primary and recurrent non-small cell lung cancer. Cancer Epidemiol Biomark Prev. 19(5):1362-72, 2010.
  6. Barletta JA, Yeap BY, Chirieac LR. The Prognostic Significance of Grading in Lung Adenocarcinoma. Cancer. 116(3):659-69, 2010.
  7. Barletta JA, Perner S, Iafrate AJ, Yeap BY, Weir BA, Johnson LA, Johnson BE, Meyerson M, Rubin MA, Travis WD, Loda M, Chirieac LR. Clinical Significance of TTF-1 Protein Expression and TTF-1 Gene Amplification in Lung Adenocarcinoma. J Cell Molec Med. 13(8B):1977-86, 2009.
  8. Rodig SJ, Mino-Kenudson M, Dacic S, Yeap BY, Shaw A, Barletta JA, Stubbs H, Law K, Lindeman N, Mark E, Janne PA, Lynch T, Johnson BE, Iafrate AJ, Chirieac LR. Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res. 15;15(16):5216-23, 2009.
  9. Howard SA, Barletta JA, Klufas RA, Saad A, De Girolami U. Best cases from the AFIP: osmotic demyelination syndrome. Radiographics. 29(3):933-8, 2009.
  10. Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M. Characterizing the cancer genome in lung adenocarcinoma. Nature. 450(7171):893-8, 2007.
  11. Tihan T, Barletta J, Parney I, Lamborn K, Sneed PK, Chang S. Prognostic value of detecting recurrent glioblastoma multiforme in surgical specimens from patients after radiotherapy: Should pathology evaluation alter treatment decisions? Human Pathol. 37(3):272-82, 2006.
  12. Koneru M, Monu N, Schaer D, Barletta J, Frey AB.3. Defective adhesion in tumor infiltrating CD8+ T cells. J Immunol. 15;176(10):6103-11, 2006.
  13. Schmidt BL, Tambeli CH, Barletta J, Luo L, Green P, Levine JD, Gear RW. Altered nucleus accumbens circuitry mediates pain-induced antinociception in morphine tolerant rats. J Neurosci. 22(15): 6773-6780, 2002.
  14. Dina OA, Barletta J, Chen X, Mutero A, Martin A, Messing RO, Levine JD. Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. J Neurosci. 20(22):8614-8619, 2000.
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<Tuesday, September 16, 2014>
12:00 PM

GYN 14-headed scope
12:00 PM

Cotran Conference Center
1:00 PM
Dr. Justine Barletta
Cotran Conference Center
2:15 PM

Surg path cutting room
2:30 PM

Autopsy suite
3:00 PM
Dr. Padera
Cotran Conference Center
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