Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Jonathan Alfred Fletcher, M.D.

Associate Professor of Pathology, Harvard Medical School



Academic Activities:

Office
75 Francis Street
TH-5-528 Thirn Building
Boston,MA 02115
Email1: jfletcher@partners.org
Education and Training:

Medical School - : Boston University School of Medicine M.D.
Internship 7/1/81 - 6/30/82 : Boston University Hospital
Residency 7/1/82 - 6/30/84 : Boston University Hospital
Residency 7/1/84 - 6/30/85 : Boston University Hospital
Fellowship 07/01/84 - 6/30/86 : Dana-Farber Cancer Institute
Fellowship 07/01/86 - 6/30/87 : Dana-Farber Cancer Institute
Fellowship 07/01/88 - 6/30/89 : Brigham and Women's Hospital

Clinical Specialties:
  • Cytogenetics
Research Interests:
  • Cancer
Publication:
  1. Xiao S, McCarthy J, Aster JC, Fletcher JA. ZNF198-FGFR1 transforming ability depends on a novel proline-rich ZNF198 oligomerization domain. Blood 2000; 96:699-704.
  2. Kroll TG, Pecciarini L, Chen C-J, Mueller E, Sarraf P, Spiegelman BM, Fletcher JA. PAX8-PPARgamma1 fusion in human thyroid carcinoma. Science 2000; 289:1357-1360.
  3. French CA, Miyoshi I, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde A, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol 2001; 159:1987-1992.
  4. Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD, Fletcher JA. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001; 61:8118-8121.
  5. French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde A, Fletcher JA. BRD4-NUT fusion oncogene: A novel mechanism in aggressive carcinoma. Cancer Res 2003; 63:304-307.
  6. Davis IJ, Hsi BL, Arroyo JD, Vargas SO, Yeh YA, Motyckova G, Valencia P, Perez-Atayde AR, Argani P, Ladanyi M, Fletcher JA, Fisher DE. Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc Natl Acad Sci U S A 2003;100:6051-60656.
  7. Heinrich MC, Corless C, Duensing A, McGreevey L, Chen C-J, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CDM, Fletcher JA. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003; 299:708-710.
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