Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Jeffery Lorne Kutok, M.D.,Ph.D.

   Associate Professor of Pathology
Academic Activities:
LAb
Thorn Building Room 603
20 Shattuck Street
Boston,MA 02115
Email1: 		Office
Thorn Building 6th floor
Room 612A
Boston,MA 02115
Email1: jkutok@partners.org
Education and Training:

Medical School 1988 - 1995 : State University of New York, Stony Brook School of Medicine And Biomedical Sciences M.D.
Graduate School 1988 - 1995 : State University of New York, Stony Brook School of Medicine and biomedical Sciences. Ph.D.
Residency 1995 - 1997 : Brigham and Women's Hospital
Fellowship 1997 - 1998 : Brigham and Women's Hospital

Clinical Specialties:
  • Hematopathology
  • Molecular Diagnostics
Research Interests:
  • Leukemia
  • Lymphoma
  • Oncogenesis
  • Signalling pathway
  • Chromosomal translocation
  • Receptor
  • Gene expression profiling
  • Mouse models
  • Hematopoiesis
  • Myeloproliferative disorder
  • Marker identification
Publication:
  1. Juszczynski P, Kutok JL, Li C, Mitra J, Aguiar RC, Shipp MA. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Mol Cell Biol. 2006;26(14):5348-59
  2. Rodig SJ, Abramson JS, Pinkus GS, Treon SP, Dorfman DM, Dong HY, Shipp MA, Kutok JL. Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H).Clin Cancer Res. 2006 1;12(23):7174-9
  3. Rodig SJ, Savage KJ, LaCasce AS, Weng AP, Harris NL, Shipp MA, Hsi ED, Gascoyne RD, Kutok JL. Expression of TRAF1 and Nuclear c-Rel Distinguishes Primary Mediastinal Large Cell Lymphoma from Other Types of Diffuse Large B Cell Lymphoma. Am J Surg Path. 2007 Jan;31(1):106-12.
  4. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27;316(5824):604-8.
  5. Gaulard P, Pileri S, Stein H, Harris NL, Jaffe ES, Kovrigina A, Kutok JL, Moller P. Primary mediastinal (thymic) large B-cell lymphoma . In WHO Classification Of Tumors: Tumours Of Hematopoietic And Lymphoid Tissues. 2nd edition. Lyon, France. IARC 2008.
  6. Kutok JL and Wang F. EBV Spectrum of Disease. Annual Review of Pathology: Mechanisms of Disease 2006, Vol. 1: Page 375 - 404. A. Abbas, J Downing, V., Kumar eds.
  7. Kutok JL. Tumors of the Hemopoietic System. In: Fletcher CDM, ed. Diagnostic Histopathology of Tumors. Churchill Livingstone 3rd edition 2007
  8. Rodig SJ, Ouyang J, Juszczynski P, Currie T, Law K, Neuberg DS, Rabinovich GA, Shipp MA, Kutok JL. AP1-dependent Galectin-1 Expression Delineates Classical Hodgkin and Anaplastic Large Cell Lymphomas from Other Lymphoid Malignancies with Shared Molecular Features. Clin Cancer Res. 2008 Jun 1;14(11):3338-44.
  9. Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K.Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol. 2008 Apr;9(4):405-14. Epub 2008 Mar 9.
  10. Juszczynski P, Ouyang J, Monti S, Rodig SJ, Takeyama K, Abramson J, Chen W, Kutok JL, Rabinovich GA, and Shipp MA. The AP1-dependent secretion of galectin-1 by Reed–Sternberg cells fosters immune privilege in classical Hodgkin lymphoma. Proc Natl Acad Sci U S A. 2007 August 7; 104(32): 13134–13139.
  11. Wu D, Dutra B, Lindeman N, Takahashi H, Takeyama K, Harris NL, Pinkus GS, Longtine J, Shipp MA, and Kutok JL. No evidence for the JAK2 (V617F) or JAK2 exon 12 mutations in primary mediastinal large B-cell lymphoma. Diagn Mol Pathol. In press.
  12. Kim JM, Parmar K, Huang M, Weinstock DM, Ruit CA, Kutok JL, D'Andrea AD.Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell. 2009 Feb;16(2):314-20.
  13. Aster J and Kutok J. Complexity made simple in Diffuse large B cell lymphoma. Clin Cancer Res. 2009 Sep 1;15(17):5291-3.
  14. Kutok JL, Yang X, Folkerth R, Adra CN. Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues. J Cell Mol Med. 2009 Oct 10. [Epub ahead of print]
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