Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Leslie Eric Silberstein, M.D.

, Harvard Medical School

Academic Activities:

One Blackfan Circle
Karp Family Research Building
Boston,MA 02115
Education and Training:

Medical School - : University of Leiden M.D.
Fellowship 7/1/81 - 6/30/83 : Tufts-New England Medical Center Hospital
Fellowship 7/1/80 - 6/30/81 : Tufts-New England Medical Center Hospital
Residency 7/1/78 - 6/30/80 : Saint Francis Hospital and Medical Center
Internship 7/1/77 - 6/30/78 : D.C. General Hospital

Clinical Specialties:
  • Transfusion Medicine
Research Interests: Publication:
  1. Rao SP, Riggs JM, Friedman DF, Scully M, LeBien TW, Silberstein LE. Biased VH gene usage in early lineage human B cells: Evidence for preferential rearrangement in the absence of selection. J Immunol 1999; 163:2732-2740.
  2. Honczarenko M, Douglas RS, Mathias C, Lee B, Ratajczak MZ, Silberstein LE. SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells. Blood 1999; 94:2990-2998
  3. Malka M, Rozmyslowicz T, Lee B, Murphy SL, Pietrzkowski Z, Gaulton GN, Silberstein LE, Ratajczak MZ. Bone marrow CD34+ cells and megakaryoblasts secrete B-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV. J Clin Invest 1999; 104:1739-1749.
  4. Cunto G, Honczarenko M, Przybilski G, Monroe J, Silberstein LE. Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV-related antigens. Blood 2000; 95:1393-1399.
  5. Silberstein LE, Toy P. Research opportunities in transfusion medicine. J Am Med Assoc 2001; 285(5):577-580.
  6. Marek Honczarenko, Yi Le, Aleksandra M. Glodek, Marcin Majka, James J. Campbell, Mariusz Z. Ratajczak, and Leslie E. Silberstein. CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor. Blood 2002 100:2321-2329.
  7. Glodek, Aleksandra M., Honczarenko, M., Le,Y., Campbell, J.J., Silberstein, L.E., Sustained Activation of Cell Adhesion is a Differentially Regulated Process in B Lymphopoiesis. Journal of Experimental Medicine, 197:4, 1-14, 2003.
  8. Burger, M., Glodek, A., Hartmann, T., Schmitt-Graff, A., Silberstein, L.E., Fujii, N., Kipps, T., Burger, J. Functional Expression of CXCR4 (CD184) on Small-Cell Lung Cancer Cells Mediates Migration, Integrin Activation, and Adhesion to Stromal Cells. Oncogene, 22, 8093-8101, 2003.
  9. Silberstein, L.E., Cunningham, M.J. Autoimmune Hemolytic Anemias, In: Blood Banking and Transfusion Medicine, Basic Principles & Practice, eds Hillyer, C.D., Silberstein, L.E., Ness, P.M., Anderson, K.C., Churchill Livingstone, 2003.
  10. Benjamin, R.J., Friedman, D.F., Silberstein, L.E., Sloan, S.R., Webb, I. Transfusion Medicine, In: Nathan and Oski’s Hematology of Infancy and Childhood, eds Nathan, D.G., Orkin, S.H., Look, A.T., Ginsberg, D., W.B. Saunders, Philadelphia, PA. 2003.
  11. Sloan, S.R. and Silberstein, L. E. Transfusion Medicine. In: Clinical Hematology and Oncology, Presentation, Diagnosis, and Treatment, eds. Furie, B., Cassileth, P. A., Atkins, M. B., Mayer, R. J., Churchill Livingstone, 2003.
  12. Campbell, J., Sloan, S., Silberstein, L. E., “Leukocyte Trafficking,” In: Hematology: Basic Principles and Practice, 4th Edition. Eds. Hoffman et al. 2005.
  13. Le, Y., Honczarenko, M., Glodek, A.M., Ho, D., Silberstein, L.E. CXC Chemokine Ligand 12-Induced Focal Adhesion Kinase Activation and Segregation into Membrane Domain is Modulated by Regulator of G Protein Signaling 1 in Pro-B Cells. Journal of Immunology, 2582-2590, 2005.
  14. Mazo, I.B., Honczarenko, M., Leung, H., Cavanagh, L.L., Bonasio, R., Weninger, W., Engelke, K., Xia, L., McEver, R.P., Koni, P.A., Silberstein, L.E., von Andrian, U.H. Bone Marrow Is a Major Reservoir and Site of Recruitment for Central Memory CD8+ T Cells. Immunity, 22(2):259-270, 2005.
  15. Honczarenko, M., Lu, B., Nicholson-Weller, A., Gerard, N.P., Silberstein, L.E., Gerard, C. C5L2 receptor is not involved in C3a/C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12. Leukemia. Doi: 10.1038/sj.leu.2403862. [Epub ahead of print]. 2005.
  16. Honczarenko, M., Ratajczak, M.Z., Nicholson-Weller, A., Silberstein, L.E. Complement C3a Enhances CXCL12 (SDF-1)-Mediated Chemotaxis of Bone Marrow Hematopoietic Cells Independently of C3a Receptor (C3aR). J. Immunology. 2005. In Press.
  17. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells. 2006;24(4):1030-1041.
  18. Honczarenko M, Glodek AM, Swierkowski M, Na IK, Silberstein LE. Developmental stage-specific shift in responsiveness to chemokines during human B-cell development. Exp. Hematol. 2006 Aug;34(8):1093-1100.
  19. Zhu D, Hattori H, Jo H, Jia Y, Subramanian K, Loison F, You J, Le Y, Honczarenko M, Silberstein LE, Luo H. Deactivation of phosphatidylinositol 3,4,5-triphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci USA. 2006 Oct 3;103(40):14836-14841.
  20. Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007 Mar;47(3):442-451.
  21. Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci USA. 2007 Jun 19;104(25):10494-9.
  22. Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia. 2007 Aug;12(8):1723-32.
  23. Le Y, Zhu BM, Harley B, Park S, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen A and Silberstein LE. SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity. 2007 Nov 26;27 (5):811-823.
  24. Jia Y, Loison F, Li Y, Erneux C, Park P, Gao C, Chai L, Silberstein L, Schurmans and Luo R. Inositol trisphosphate kinases B (InsP3KB) as a physiological modulator of myelopoiesis, PNAS, 2008 Mar 25;105(12):4739-44.
  25. Steigman SA, Armant M, Bayer-Zwirello L, Kao GS, Silberstein L, Ritz J, Fauza DO. Preclinical regulatory validation of a 3-stage amniotic mesenchymal stem cell manufacturing protocol. Journal Pediatric Surgery. 2008 Jun;43(6):1164-9. PMCID: PMC2478751
  26. Jin H, Oyoshi MK, Le Y, Bianchi T, Koduru S, Mathias CB, Kumar L, Le Bras S, Young D, Collins M, Grusby MJ, Wenzel J, Bieber T, Boes M, Silberstein LE, Oettgen HC, Geha RS. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in human and mice. Journal Clinical Investigation. 2009 Jan;119(1):47-60. PMID: 19075398
  27. Le Y, Xu L, Lu J, Fang J, Nardi V, Chai L, Silberstein LE. FAK silencing inhibits leukemogenesis in BCR/ABL transformed hematopoietic cells. American Journal of Hematology. 2009 May; 84(5):273-8.
  28. Sarraj B, Massberg S, Li Y, Kasorn A, Subramanian K, Loison F, Silberstein LE, von Andrian U, Luo HR. Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. Journal of immunology. 2009 Jun 1;182(11): 7190-200.
  29. Lu J, Jeong HW, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Yupoma, Chai L. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One. 2009; 4(5):e5577. Epub 2009 May 18.
  30. Gao H, Le Y, Wu X, Silberstein LE, Giese RW, Zhu Z. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Research, 70 (1), 202-10, 2010.
<June 2019>

<Monday, June 24, 2019>
8:00 AM

Cotran Conference Center
8:00 AM

Autopsy suite
9:00 AM

Clinical Lab conference room
3:00 PM

Dammin signout suite
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