Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Office
55 Fruit Street
WRN-3-334
Boston,MA 02114
Email1: mfrosch@partners.org
Education and Training:

Medical School - : Harvard Medical School M.D.
Graduate School - : Harvard University Graduate School of Arts And Sciences Ph.D.
Residency 1987 - 1992 : Brigham and Women's Hospital

Clinical Specialties:
  • Neuropathology
Research Interests: Publication:
  1. Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of CAA in Transgenic Mouse Models of AD. J Neuropathol Exp Neurol. 2005, 64:588-94.
  2. Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of Cerebral Amyloid Angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci. 2006, 26:365-371.
  3. Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis. 2006. 24:516-24.
  4. Zhang-Nunes SX, Maat-Schieman MLC, van Duinen SG, Roos RAC, Frosch MP, Greenberg SM. The Cerebral â-Amyloid Angiopathies: Hereditary and Sporadic. Brain Pathol. 2006. 16:30-9.
  5. Prada C, Garcia-Alloza M, Zhang-Nunes SX, Betensky RA, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of Aâ from Cerebral Amyloid Angiopathy revealed by quantitative in vivo imaging. J. Neurosci. 2007, 27:1973-80.
  6. Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, DeKosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular Imaging With Pittsburgh Compound B Confirmed at Autopsy: A Case Report. Arch Neurol. 2007; 64:431-434.
  7. Freeman SH, Raju S, Hyman BT, Frosch MP, Irizarry MC. Plasma Aâ levels do not reflect brain Aâ levels. J. Neuropathol Exp Neurol. 2007, 66:264-271.
  8. Simon DK, Rodriguez ML, Frosch MP, Quackenbush EJ, Fekse SK, Natowicz MR. A unique familial leukodystrophy with adult onset dementia and abnormal glycolipid storage: a new lysosomal disease? J Neurol Neurosurg Psychiat 1998; 65:251-254.
  9. Soriano SG, Coxon A, Wang YF, Frosch MP, Lipton SA, Hickey, PR, Mayadas TN. Mice deficient in Mac-1 [CD11b/CD18] are less susceptible to cerebral ischemia reperfusion injury, Stroke, 1999; 30:134-139
  10. Berezovska O. McLean P, Knowles R, Frosch, MP, Lu SM, Lux SE, Hyman B. Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience, 1999; 93:433-439.
  11. Albarracin CT, Frosch MP, Chin WW. The gonadotrophin-releasing hormone receptor gene promoter directs pituitary-specific oncogene expression in transgenic mice. Endocrinology, 1999; 140:2415-2421.
  12. Berezovska O, Frosch MP, McLean P, Knowles R, Koo E, Kang D, Lu FM, Lux SE, Shen OJ, Tonegawa S, Human BT. Presenilin 1 facilitates Notch 1 effect on neurite outgrowth in primary mammalian neurons. Molec Brain Res, 1999; 69:273-280.
  13. Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Koo EH. Presenilin 1 alters the processing of ß-catenin: evidence for dominant negative activity of Alzheimer's disease linked mutations on ß-catenin half-life. J Neurosci, 1999; 19:4229-4237.
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