Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Michelle S. Hirsch, M.D.,Ph.D.

Associate Professor of Pathology, Harvard Medical School
Chief, Genitourinary Pathology Service
Associate Pathologist, Genitourinary Pathology Division
Associate Pathologist, Women's & Perinatal Pathology Division
Academic Activities:
Renal Epithelial Tumors, Ovarian Epithelial Tumors, Biomarkers, Translational Reseach
75 Francis Street
Boston, MA 02115
Education and Training:

Graduate School 1991 - 1996 : Boston University School of Medicine Ph.D.
Medical School 1996 - 1999 : Boston University School of Medicine M.D.
Residency 1999 - 2002 : Brigham and Women's Hospital
Fellowship 2002 - 2002 : Brigham and Women's Hospital
Fellowship 2002 - 2003 : Brigham and Women's Hospital

Clinical Specialties:
  • Genitourinary Pathology
  • Women's and Perinatal Pathology
  • Anatomic Pathology
Research Interests:
  • Ovarian cancer
  • Endometrial cancer
  • Kidney diseases
  1. Hirsch MS, Weinstein MH, Thomas A, Dal Cin P. Identical karyotypes in synchronous bilateral clear cell renal cell carcinomas. Can Genet Cyto, 2002;139:86-87.
  2. Nascimento AF, Hirsch MS, Cviko A, Quade BJ, Nucci MR. The role of CD10 staining in distinguishing invasive endometrial adenocarcinoma from adenocarcinoma involving adenomyosis. Mod Pathol, 2003;16:22-27.
  3. Hirsch MS, Faquin WC, Krane JF. Thyroid transcription factor-1, but not p53 is helpful in distinguishing moderately differentiated neuroendocrine carcinoma of the larynx from medullary carcinoma of the thyroid. Mod Pathol, 2004;17:631-636.
  4. Browne TJ , Hirsch MS, Brodsky G, Welch WR, Loda MF, Rubin MA. The clinical utility of AMACR (p504) and basal cell cocktail in the evaluation of prostate needle biopsies: A prospective single institution study. Hum Pathol, 2004; 35(12):1462-68.
  5. Hirsch MS, Dal Cin P, Fletcher CDM. ALK expression in reactive pseudosarcomatous myofibroblastic proliferations of the genitourinary tract. Histopathol, 2006; 48(5):569-78.
  6. Kindelberger DW, Yonghee L, Miro A, Hirsch MS, Feltmate C, Medeiros F, Callahan MJ, Garner EO, Gordon RW, Birch C, Berkowitz RS, Muto MG, Crum CP. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am J Surg Pathol, 2007; 31(2):161-169.
  7. Carlson JW, Nucci MR, Brodsky J, Crum CP, Hirsch MS. Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: The role of TTF-1, WT-1 and HPV Analysis. Histopathol 2007 (in press).
  8. Liu JF, Hirsch MS, Hang L, Matulonis UA.Prognosis and hormone receptor status in older and younger patients with advanced-stage papillary serous ovarian carcinoma. Gyn Onc, 2009, 115(3):401-406.
  9. Choueiri TK, Mosquera JM, Hirsch MS. A Case of Adult Metastatic Xp11 Translocation Renal Cell Carcinoma Treated Successfully with Sunitinib, Clin Genitourin Cancer, 2009;7(3):E93-4.
  10. Clauss A, Ng V, Liu J, Piao H, Russo M, Sheng Q, Hirsch MS, Bonome T, Matulonis U, Birrer MJ, and Drapkin R. Overexpression of Elafin, an NF-KB target gene, in ovarian carcinomas is associated with poor overall survival, 2010 Neoplasia, 2010;12(2):161-72.
  11. Laury AL, Hornick JL, Perets R, Corson J, Drapkin R, Hirsch MS. PAX8 Reliably Distinguishes Ovarian Serous Tumors from Malignant Mesothelioma. Am J Surg Pathol, 2010; 34(5):627-35.
  12. Laury AR, Perets R, Piao H, Krane JF, Barletta JA, French, C, Chirieac LR, Lis R, Loda M, Hornick JL, Drapkin, Hirsch MS. A Comprehensive Analysis of PAX8 Expression in Human Epithelial Tumors. Am J Surg Pathol 2011 (in press).
  13. Mosquera J-M, Dal Cin P, Mertz KD, Perner S, Davis IJ, Fisher DE, Rubin MA, Hirsch MS. Validation of a TFE3 Break-Apart FISH Assay in Xp11.2 Translocation Renal Cell Carcinomas, Diag Molec Pathol, 2011; 20(2): (in press).
<September 2019>

<Sunday, September 15, 2019>
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