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Ronny I. Drapkin, M.D.,Ph.D.
Assistant Professor of Pathology
Principal Investigator
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Academic Activities:
Research in the Drapkin laboratory focuses on understanding the pathogenesis and genetic alterations involved in women’s cancers, with a specific interest in ovarian cancer. A major goal is to translate what is learned at the bench into clinically useful diagnostic and therapeutic tools. To accomplish these goals, the laboratory focuses on three complementary approaches: (1) ovarian cancer genetics, (2) pathogenesis, and (3) biomarker development. All three approaches rely on integrated genomic studies, new cell culture model systems, and rigorous protein biochemistry and molecular biology.
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Office
44 Binney Street
JFB-215D DFCI
Boston,MA
02115
Email1:
ronny_drapkin@dfci.harvard.edu
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Education and Training:
Medical School
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University of Medicine and Dentistry of New Jersey
M.D.
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Graduate School
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University of Medicine and Dentistry of New Jersey
Ph.D.
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Residency
7/1/98
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:
Brigham and Women's Hospital
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Fellowship
7/1/2001
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:
Dana-Farber Cancer Institute
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Clinical Specialties:
Research Interests:
- Ovarian cancer
- Cell Proliferation
- Cancer
- Oncogenesis
- Signalling pathway
- Growth factor
- Breast Cancer
- Gene expression profiling
- Marker identification
- Pathogenesis
- Transcriptional regulation
- Cell Biology
Publication:
- Drapkin R, Crum CP, Hecht JL. Expression of Candidate Tumor Markers in Ovarian Carcinoma and Benign Ovary: Evidence for a link between epithelial phenotype and neoplasia. Human Pathol 2004; 35: 1014-1021.
- Cantor S*, Drapkin R*, Zhang F, Lin Y, Han J, Pamidi S, Livingston DM. The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. PNAS 2004; 101: 2357-2362. (* denotes equal contribution).
- Drapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR, Hecht JL. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. Cancer Res 2005; 65: 2162-2169
- Drapkin R, Hecht JL. Pathogenesis of Ovarian Cancer in Diagnostic Gynecologic and Obstetric Pathology [Crum CP and Lee KR, eds.], W.B. Saunders, Philadelphia, 2006.
- Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon RW, Cramer DW, McKeon FD, Crum CP. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol 2007, 211:26-35.
- Crum CP, Drapkin R, Miron A, Ince TA, Muto M, Kindelberger DW, Lee Y. The distal fallopian tube: a new model for pelvic serous carcinogenesis. Curr Opin Obstet Gynecol. 2007; 19: 3-9.
- Erkko H, Xia B, Nikkila J, Schleutker J, Syrjakoski K, Mannermaa A, Kallioniemi A, Pylkas K, Karppinen S-M, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Reiman M, Jukkola-Vuorinen A, Mustonen A, Kere J, Aaltonen LA, Kosma V-M, Soini Y, Drapkin RI, Livingston DM, Winqvist R. A recurrent mutation in PALB2 in Finnish cancer families. Nature 2007; 446: 316-319.
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