Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Richard Neal Mitchell, M.D.,Ph.D.

   Associate Professor of Pathology and Health Sciences and Technology
Academic Activities:
Office
77 Avenue Louis Pasteur
HNRB-7-730D
Boston,MA 02115
Email1: rmitchell@rics.bwh.harvard.edu
Education and Training:

Medical School - 1984 : Harvard Medical School M.D.
Residency 1984 - 1985 : Beth Israel Deaconess Medical Center
Residency 1985 - 1988 : Brigham and Women's Hospital
Fellowship 1988 - 1990 : Brigham and Women's Hospital

Clinical Specialties:
  • Cardiac Pathology
  • Autopsy Pathology
Research Interests:
  • Immunology
Publication:
  1. Barnes KA, Mitchell RN. Detection of functional class II-associated antigen: Role of a low density endosomal compartment in antigen processing. J Exp Med 1995; 181:1715-1727.
  2. Mitchell RN, Barnes KA, Grupp SA, Sanchez M, Misulovin Z, Nussenzweig MC, Abbas AK. Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes. J Exp Med 1995; 181:1705-1714.
  3. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Libby P. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest 1997; 100:550-557.
  4. Mitchell RN, Jonas RA, Schoen FJ. Pathology of explanted cryopreserved allograft human valves: Comparison with aortic valves from orthotopic heart transplants. J Thorac Cardiovasc Surg 1998; 115:118-127.
  5. Nagano H, Libby P, Taylor MK, Hasegawa S, Stinn JL, Tilney NL, Mitchell RN. Coronary arteriosclerosis following T cell-mediated injury in murine cardiac allografts: Role of interferon-gamma. Am J Pathol 1998; 152:1187-1197.
  6. Furukawa Y, Becker G, Stinn JL, Shimizu K, Libby P, Mitchell RN. IL-10 augments allograft arterial disease: Paradoxical effects of IL-10 in vivo. Am J Pathol 1999; 155:1929-1940.
  7. Shimizu K, Schonbeck U, Mach F, Libby P, Mitchell RN. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplants, but does not prevent graft arteriosclerosis. J Immunol 2000; 165:3506-3518.
  8. Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone marrow cells are a source of donor intimal smooth muscle-like cells in murine aortic transplant arteriopathy. Nature Med 2001; 7:738-741.
  9. Furukawa Y, Libby P, Stinn JL, Becker G, Mitchell RN. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy arteriopathy in non-immunosuppressed hosts. Am. J. Pathol. 2002;160:1077-1087.
  10. Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation 2003; 108:2113-2120.
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