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Richard Neal Mitchell, M.D.,Ph.D.

Professor of Pathology and Health Sciences and Technology, Harvard Medical School
Vice Chair for Education, Brigham and Women's Pathology
Associate Director, Health Sciences and Technology, Harvard Med

Academic Activities:
Dr. Mitchell researches the mechanisms underlying acute and chronic rejection in solid organ allografts, with specific emphasis on heart transplants. His work runs the gamut from mouse transplant models to human clinical transplantation, and is focused on understanding the specific immunologic pathways that drive rejection and ultimately graft failure. His lab is particularly interested in the mechanisms that induce the process of “chronic rejection” whereby the vessels in transplanted hearts become progressively more occluded until the grafts get starved for blood and die. The research may have much broader applicability, since the inflammatory mediators that drive the occlusive process in transplanted hearts may also be involved in mediating the vascular wall thickening that characterizes more “typical” atherosclerosis. Dr. Mitchell's laboratory uses several genetically engineered mice (so-called “knock-out” mice), which are either deficient in cell surface molecules that promote the cellular cross-talk necessary to promote rejection, or which lack particular “cytokine” mediators or their receptors.
Office
77 Avenue Louis Pasteur
HNRB-7-730D
Boston,MA 02115
Email1: rmitchell@rics.bwh.harvard.edu
Education and Training:

Medical School - 1984 : Harvard Medical School M.D.
Residency 1984 - 1985 : Beth Israel Deaconess Medical Center
Residency 1985 - 1988 : Brigham and Women's Hospital
Fellowship 1988 - 1990 : Brigham and Women's Hospital

Clinical Specialties:
  • Cardiac Pathology
  • Autopsy Pathology
Research Interests:
  • Immunology
  • Mouse models
  • Atherosclerosis
  • Cell motility
  • Transplant pathology
Publication:
  1. Shimizu K, Schonbeck U, Mach F, Libby P, Mitchell RN. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplants, but does not prevent graft arteriosclerosis. J Immunol 2000; 165:3506-3518.
  2. Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone marrow cells are a source of donor intimal smooth muscle-like cells in murine aortic transplant arteriopathy. Nature Med 2001; 7:738-741.
  3. Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation 2003; 108:2113-2120.
  4. Shimizu K, Shichiri M, Libby P, Lee RT, Mitchell RN. Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J. Clin. Invest. 2004;114:300-8.
  5. Shimizu K, Libby P, Shubiki R, Sakuma M, Wang Y, Asano K, Simon DI, Mitchell RN. Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection. Circulation. 2008;117:1997-2008.
  6. Shimizu K, Minami M, Shubiki R, Lopez-Ilasaca M, MacFarlane L, Asami Y, Li Y, Mitchell RN, Libby P. CC chemokine receptor-1 activates intimal smooth muscle-like cells in graft arterial disease. Circulation. 2009;120:1800-1813.
  7. Shimizu K, Libby P, Rocha VC, Folco EJ, Shubiki R, Grabie N, Jang S, Lichtman AH; Shimizu A, Hogg N, Simon DI, Croce K, Mitchell RN. Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection. Circulation 2011; 124:2920-3292
  8. Zhang C, Jang S, Amadi OC, Shimizu K, Lee RT, Mitchell RN. A sensitive chemotactic assay using a novel microfluidic device. Biomed Res International. 2013, article ID 373569
  9. Mitchell RN. Graft Vascular Disease: Immune Response Meets the Vessel Wall. Ann. Rev. Pathol. 2009; 4:19-47.
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