Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Stephen Charles Blacklow, M.D.,Ph.D.

Professor of Pathology, Harvard Medical School



Academic Activities:
My research laboratory has focused on the relationship between structure and function in proteins of the LDL receptor family and in human homologues of Drosophila Notch.
Office
77 Avenue Louis Pasteur
HNRB-652E
Boston,MA 02115
Email1: sblacklow@partners.org
Education and Training:

Medical School - : Harvard Medical School M.D.
Graduate School - : Harvard University Graduate School of Arts And Sciences Ph.D.
Residency 7/1/91 - 6/30/95 : Brigham and Women's Hospital
Fellowship 7/1/93 - 8/31/96 : Whitehead Institute, MIT
Professional Position 9/1/96 - 11/30/97 : Stanford University

Clinical Specialties: Research Interests:
  • Signalling pathway
  • Structural biology
  • Cancer
Publication:
  1. Gordon, WR, Roy, M, Vardar-Ulu, D, Garfinkel, M, Mansour, MR, Aster, JC, and Blacklow, SC. Structure of the Notch1 Negative Regulatory Region: Implications for Normal Activation and Pathogenic Signaling in T-ALL. Blood 2009; 113(18):4381-4390.
  2. Gordon, WR, Vardar-Ulu, D, Sanchez-Irizarry, C, Histen, G, Aster, JC, and Blacklow, SC. Structural Basis for Autoinhibition of Notch. Nat Struct and Mol Biol 2007; 14(4):295-300.
  3. Fisher, C., Beglova, N., and Blacklow, S.C. A general mode for recognition of ligands by lipoprotein receptors from the structure of an LDLR-RAP complex. Mol Cell 2006;22:277-283.
  4. Nam, Y., Sliz, P., Song, L., Aster, JC, and Blacklow, S.C. Structural basis for cooperativity in recruitment of MAML co-activators to Notch transcription complexes. Cell, 2006;124, 973-983.
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