Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Sabina Signoretti, M.D.

Associate Professor of Pathology, Harvard Medical School

Academic Activities:

75 Francis Street
TH-5-504 Thorn Building
Boston,MA 02115
Education and Training:

Medical School - : University of Rome "La Sapienza" M.D.
Residency 7/1/89 - 6/30/93 : University of Rome "La Sapienza"
Fellowship 7/1/96 - 12/31/96 : Beth Israel Hospital
Fellowship 1/1/97 - 6/30/98 : Beth Israel Hospital
Professional Position 7/1/98 - : Dana-Farber Cancer Institute
Professional Position 7/1/93 - 6/30/96 : Istituto Dermopatico Dell'immacolata

Clinical Specialties: Research Interests: Publication:
  1. Signoretti S, Montironi R Manola J, Altimari A, Tam C, Bubley G, Balk S, Thomas G, Kaplan I, Hlatky L, Hahnfeldt P, Kantoff P, Loda M. Her-2-neu expression and androgen independence in human prostate cancer. J Natl Cancer Inst 2000;92:1918-25.
  2. Signoretti S, Waltregny D, Dilks J, Isaac B, Lin D, Garraway L, Yang A, McKeon F, Montironi R, Loda M. p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol 2000;157:1769-75.
  3. Waltregny D, Leav I, Signoretti S, Soung P, Lin D, Merk F, Adam YA, Bhattacharya N, Cirenei N, Loda M. Androgen-driven prostate epithelial cell proliferation and differentiation in vivo involve the regulation of p27 kip1 through its proteasome-mediated degradation. Mol Endocrinol 2001;15:765-82.
  4. Signoretti S, Loda M. Estrogen receptor beta in prostate cancer: brake pedal or accelerator? Am J Pathol 2001;159:13-6
  5. Signoretti S, di Marcotullio L, Richardson A, Ramaswamy S, Carrano A C, Isaac B, Rue M, Monti F, Loda M and Pagano M. Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J Clin Invest. 2002;110:633-4
  6. Bardeesy N, Sinha M, Hezel A F, Signoretti S, Hathaway N A, Sharpless N E, Loda M, Carrasco D R and DePinho RA. Loss of the Lkb1 tumor suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002;419:162-7.
  7. Graner E, Tang D, Rossi S, Baron A, Migita T, Weinstein LJ, Lechpammer M, Huesken D, Zimmermeann J, Signoretti S, Loda M. The isopeptidase USP2a regulates the stability of Fatty Acid Synthase in prostate cancer. Cancer Cell. 2004; 5:253-61
  8. Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC. Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res. 2004; 64:8867-75
<June 2019>

<Monday, June 24, 2019>
8:00 AM

Cotran Conference Center
8:00 AM

Autopsy suite
9:00 AM

Clinical Lab conference room
3:00 PM

Dammin signout suite
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