Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
Login Skip Navigation Links
  Skip Navigation Links
HomeExpand Home


Submit new announcement
Stanislawa Weremowicz, Ph.D.

Assistant Professor of Pathology, Harvard Medical School

Academic Activities:

75 Francis Street
AL-3 Amory Building
Boston,MA 02115
Education and Training:

College - 1972 : Veterinary Faculty, Academy of Agriculture, Warsaw M.Sci.
Graduate School - 1979 : Veterinary Faculty, Academy of Agriculture, Warsaw Ph.D.
Post-Doc 1985 - 1990 : Harvard Medical School, Boston MA
Post-Doc 1991 - 1994 : Brigham and Women’s Hospital, Boston, MA

Clinical Specialties:
  • Cytogenetics
Research Interests: Publication:
  1. Weremowicz S, Fox EA, Morton CC, Vallee BL. Localization of the human angiogenin gene to chromo- some band 14q11, proximal to the T cell receptor alpha/delta locus. Am J Hum Genet 1990;47:973-981.
  2. Weremowicz S, Fox EA, Morton CC, Vallee BL. The placental ribonuclease inhibitor (PRI) gene is located on chromosome sub-band 11p15.5. Genomics 1990;8:717-721.
  3. Weremowicz S, Kupsky WJ, Morton CC, Fletcher JA. Cytogenetic evidence for a chromosome 22 tumor suppressor gene in ependymoma. Cancer Genet Cytogenet 1992;61:193-196.
  4. Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW. Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic-specific subunit and evidence for an associated partner. Mol Cell Biol 1993;5604-5612.
  5. Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA. Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: Potential role in dicarboxylic aminoaciduria and neurodegenerative disorders. Genomics 1994;20:335-336.
  6. Robinson LJ, Weremowicz S, Morton CC, Michel T. Isolation and chromosomal localization of the human endothelial nitric oxide synthase gene. Genomics 1994;19:350-357.
  7. Weremowicz S, Kozakewich HP, Haber D, Park C, Morton CC, Fletcher JA. Identification of genetically aberrant cell lineages in Wilms tumors. Genes Chromosom Cancer 1994;10:40-48.
  8. Sargent MS, Weremowicz S, Rein MS, Morton CC. Translocations in 7q22 define a critical region in uterine leiomyomata. Cancer Genet Cytogenet 1994;77:65-68.
  9. Magovcevic I, Weremowicz S, Morton CC, Fong S-L, Berson EL, Dryja TP. Mapping of the human cone transducin ? subunit (GNAT2) gene to 1p13 and negative mutation analysis in patients with Stargardt's disease. Genomics 1995;25:288-290.
  10. Schoenberg Fejzo M, Yoon S-J, Montgomery KT, Rein MS, Weremowicz S, Krauter KS, Dorman TE, Fletcher JA, Mao J, Moir DT, Kucherlapati RS, Morton CC. Identification of a YAC spanning the translocation breakpoints in uterine leiomyomata, pulmonary chondroid hamartoma and lipoma. Physical mapping of the 12q14-15 breakpoint region in uterine leiomyomata. Genomics 1995;26:265-271.
  11. Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS. Trinucleotide repeats at the rad locus: Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q. Diabetes 1995;44:243-247.
  12. Ashar H, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K. Disruption of the architectural factor HMGI-C: DNA-binding A-T hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 1995;82:1-20.
  13. Gorn AH, Rudolph SM, Flannery MR, Morton CC, Weremowicz S, Wang J-T, Krane SM, Goldring SR. Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone: The first intracellular domain modulates ligand binding and signal transduction. J Clin Invest 1995;95:2680-2691.
  14. Yi H, Morton CC, Weremowicz S, McBride W, Kelly K. Localization of the PAC1 gene which encodes a MAP kinase phosphatase to human chromosome 2 in bands p11.2-q11. Genomics 1995;28:92-96.
  15. Zhao Y, Bjørbæk, Weremowicz S, Morton CC, Moller DE. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: Growth factor-stimulated kinase function and nuclear translocation. Mol Cell Bio 1995;15:4353-4363.
  16. Elson A, Kozak CA, Morton CC, Weremowicz S, Leder P. The protein tyrosine phosphatase ? gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics 1996;31:373-375.
  17. Schoenberg Fejzo M, Ashar HR, Krauter KS, Powell WL, Rein MS, Weremowicz S, Yoon S-J, Kucherlapati RS, Chada K, Morton CC. Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. Genes Chromosom. Cancer 1996;17:1-6.
  18. Wilkins-Haug LE, Sandstrom M McH, Weremowicz S. Fluorescence in-situ hybridization for the detection of aneuploidy from archived fetal cells. Ob Gyn 1996;88:684-687.
  19. Stewart AFR, Richard III CW, Suzow J, Stephan D, Weremowicz S, Morton CC, Adra CN. Cloning of human RTEF-1, a transciptional enhancer factor-1 related gene preferentially expressed in skeletal muscle: Evidence for an ancient multigene family. Genomics 1996;36:68-76.
  20. Schneider MC, Rodriguez AM, Nomura H, Zhou J, Morton CC, Reeders ST, Weremowicz S. A gene similar to PKD1 maps to chromosome 4q22: A candidate gene for PKD2. Genomics 1996;38:1-4.
  21. Pedeutour F, Quade BJ, Weremowicz S, Dal Cin P, Ali S, Morton CC. Localization and expression of the human estrogen receptor beta gene in uterine leiomyomata. Genes Chromosomes Cancer 1998;23:361-366.
  22. Rein MS, Powell WL, Walters FC, Weremowicz S, Cantor RM, Barbieri RL, Morton CC. Cytogenetic abnormalities in uterine myomas are associated with myoma size. Molec Human Repro 1998;4:83-86.
  23. Dal Cin P, Quade BJ, Weremowicz S, Morton CC Pauwels P, Van Den Berghe H. Primary parauterine leiomyoma with a t(6;14). Genes Chromosomes Cancer 1999;26:383-384.
  24. Weremowicz S, Morton CC. Is HMGIC rearranged due to cryptic paracentric inversion of 12q in karyotypically normal uterine leiomyomas? Genes Chromosomes Cancer 1999;24:172-173.
  25. Sornberger KS, Weremowicz S, Williams AJ, Quade BJ, Ligon AH, Pedeutour F, Vanni R, Morton CC. Expression of HMGIY in three uterine leiomyomata with complex rearrangements of chromosome 6. Cancer Genet Cytogen 1999;114:9-16
  26. Pedeutour F, Quade BJ, Sornberger K, Tallini G, Ligon AH, Weremowicz S, Morton CC. Dysregulation of HMGIC in a uterine lipoleiomyoma with complex rearrangement including chromosomes 7, 12 and 14. Genes Chromosomes Cancer 2000;27:209-215.
  27. Weremowicz S, Sandstrom DJ, Morton CC, Niedzwiecki CA, Sandstrom MMcH, Bieber FR. FISH for rapid detection of aneuploidy: Experience in 911 prenatal cases. Prenat Diagn 2001;21:262-269.
  28. Nucci MR, Weremowicz S, Tallini G, Sornberger K, Morton CC, Quade BJ. Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva. Genes Chromosomes Cancer 2001;32:172-176.
  29. Quade BJ, Dal Cin P, Neskey DM, Weremowicz S, Morton CC. Intravenous leiomyoma: is there a genetic mechanism in common with uterine leiomyoma?Modern Pathology 2002;15:351-356.
  30. Yuasa T, Bhuvarahamurthy V, Weremowicz S, Morton CC, Guo L, Zhou J. The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human. Genomics 2002;79:376-386.
  31. Dal Cin P, Quade BJ, Neskey DM, Kleinman MS, Weremowicz S, Morton CC.
  32. Quade BJ, Weremowicz S, Nesky DM, Vanni R, Ladd C, Dal Cin P, Morton CC. Fusion transcripts are not a common molecular mechanism in uterine leiomyomata with rearrangement in 12q15. Cancer Res 2003;63:1351-1359.
  33. Gross KL, Neskey DM, Manchanda N, Weremowicz S, Kleinman MS, Nowak RA, Ligon AH, Rogalla P, Drechsler K, Bullerdiek J, Morton CC. HMGA2 expression in uterine leiomyomata and myometrium: Quantitative analysis and tissue culture studies. Genes Chromosomes Cancer 2003;38:68-79.
  34. Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti-Domenici J, Bae YK, Monitto CL, Merlos-Suarez A, Han J, Hulette CM, Richardson A, Morton CC, Marks J, Duyao M, Hruban E, Gelman R, Polyak K. A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci USA 2003;100(19):10939-10946.
  35. Oliveira AM, Hsi B-L, Weremowicz S, Perez-Atayde AR, Rosenberg AE, Dal Cin P, Joseph N, Bridge JA, Fletcher JA. USP6(Tre2) fusion oncogenes in aneurysmal bone cyst. Cancer Res 2004;64:1920-1923.
  36. Dal Cin P, Thomas A, Weremowicz S. An intragenic rearrangement of HMGA2 is not necessary to occur for lipoma formation. Cancer Genet Cytogenet 2004;149:178-179.
  37. Kim S-H, Ma X, Weremowicz S, Ercolino T, Powers C, Mlynarski W, Bashan KA, Warram JH, Mychaleckyj J, Rich SS, Krolewski AS, Doria A. Identification of a locus for maturity-onset diabetes of he young on chromosome 8p23. Diabetes 2004;53:1375-1384.
  38. Veugelers M, Bressan M, McDermott DA, Weremowicz S, Morton CC, Mabry CC, Lefaivre J-F, Zunamon A, Destree A, Chaudron J-M, Basson CT. Mutation of perinatal myosin heavy chain associated with a Carney complex variant. N Engl J Med 2004;351:5:460-469.
  39. Fisher RA, Nucci MR, Thaker HM, Weremowicz S, Genest DR, Castrillon DH. Complete hydatidiform mole retaining a chromosome 11 of maternal origin: molecular genetic analysis of a case. Modern Pathology 2004;17:1155-1160.
  40. Leach N, Cole S, Sandstrom DJ, Weremowicz S. Novel pericentric inversion of chromosome 14 involving the rRNA gene cluster. (Prenat Diagn in press)
  41. Yao J, Weremowicz S, Feng B, Gentleman RC, Marks JR, Gelman R, Brennan C, Polyak K. Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression. Cancer Res 2006; 66:4065-4078.
  42. Weremowicz S, Sandstrom DJ, Morton CC, Miron PM. Validation of DNA probes for preimplantation genetic diagnosis (PGD) by fluorescence in situ hybridization (FISH). Prenat Diagn 2006, 26:1042-1050
  43. Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao Y, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, Nikolsky Y, Gelman RS, Polyak K. Molecular definition of breast tumor heterogeneity. Cancer Cell 2007, 11: 259-273.
  44. Leach NT, Chudoba I, Stewart TV, Holmes LB, Weremowicz S. Maternally inherited duplication of chromosome 7, dup(7)(p11p12), associated with mild cognitive deficit without features of Silver-Russell syndrome. Am J Med Genet 2007; 143:1489-1493.
  45. Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Greulich H, Steward CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier J, Hinkle G, Root DE, Roberst TM, Lander ES, Polyak K, Hahn WC. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 2007; 129:1065-1079.
  46. Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, Schnitt S, Polyak K. Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 2008; 13:394-406.
<June 2019>

<Monday, June 24, 2019>
8:00 AM

Cotran Conference Center
8:00 AM

Autopsy suite
9:00 AM

Clinical Lab conference room
3:00 PM

Dammin signout suite
Copyright 2008 - 2019, BWH Pathology, All rights reserved.