Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Office
75 Francis Street
TH-6-630a Thorn Building
Boston,MA 02115
Email1: taince@partners.org
Education and Training:

Medical School 1982 - 1988 : Hacettepe University Medical School M.D.
Graduate School 1989 - 1995 : Cornell University Graduate School of Medical Sciences Ph.D.
Fellowship 9/1/95 - 6/30/98 : Memorial Sloan-Kettering Cancer Center
Residency 7/1/98 - 6/30/00 : Massachusetts General Hospital
Fellowship 7/1/00 - 6/30/01 : Brigham and Women's Hospital

Clinical Specialties:
  • Breast Pathology
  • Women's and Perinatal Pathology
Research Interests:
  • Breast Cancer
  • Cancer stem cell
Publication:
  1. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, and Daley GQ. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008; 451:141-6.
  2. Lerou PH, Yabuuchi A, Huo H, Takeuchi A, Shea J, Cimini T, Ince TA, Ginsburg SE, Racowsky C, and Daley GQ. Human Embryonic Stem Cell Derivation from Poor-Quality Embryos. Nat Biotechnol. 2008; 26:212-4.
  3. Ince TA, Richardson AL, Bell G, Saitoh M, Godar S, Karnoub AE, Iglehart JD and Weinberg RA. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell 2007;12(2):160-170.
  4. Lensch MW, Ince TA. The terminology of teratocarcinomas and teratomas. Nat Biotechnol. 2007; 25(11):1211.
  5. Dinulescu T, Ince TA, Quade BJ, Crowley D and Jacks T. Role of Oncogenic K-RAS in the Development of Endometriosis and Endometrioid Ovarian Adenocarcinoma. Nat Med. 2005;11(1):63-70.
  6. Witkiewicz AK, Hecht JL, Cviko A, McKeon FD, Ince TA, Crum CP. Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells. Hum Pathol. 2005;36(2):154-61.
  7. Hecht JL, Ince TA, Baak JP, Baker HE, Ogden MW, Mutter GL. Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis. Mod Pathol. 2005;18: 324-30.
  8. Moore SD, Herrick SR, Ince TA, Kleinman MS, Cin PD, Morton CC, Quade BJ. Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Cancer Res. 2004; 64(16):5570-7.
  9. Nucci MR, Castrillon DH, Bai H, Quade BJ, Ince TA, Genest DR, Lee KR, MutterGL, Crum CP. Biomarkers in diagnostic obstetric and gynecologic pathology: Adv. Anat Pathol. 2003; 10(2):55-68.
  10. Watnick RS, Cheng YN, Rangarajan A, Ince TA, Weinberg RA. Ras modulates Myc activity to repress thrombospondin-1 expression and increasetumor angiogenesis. Cancer Cell. 2003; 3(3):219-31.
  11. Urist MJ, Di Como CJ, Lu ML, Charytonowicz E, Verbel D, Crum CP, Ince TA,McKeon FD, Cordon-Cardo C. Loss of p63 expression is associated with tumor progression in bladder cancer. Am J Pathol. 2002;161(4):1199-206.
  12. Ince TA, Cviko AP, Quade BJ, Yang A, McKeon FD, Mutter GL, Crum CP. p63 coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract. Am J Pathol. 2002;161(4):1111-7.
  13. Ince TA, Weinberg RA. Functional genomics and the breast cancer problem. Cancer Cell. 2002;1:15-7.
  14. Mutter GL, Ince TA, Baak JPA, Kust GA, Zhou X-P, Eng C. Molecular identification of latent precancers in histologically normal endometrium. Cancer Res. 2001; 61:4311-14.
  15. Ince TA, Lin Y, Scotto KW. Optimization of a versatile in vitro transcription assay for the expression of multiple start site TATA-less promoters. Biochemistry. 2001; 40(43):12959-66.
  16. Ince TA , Johnson RA, Scotto KW. Transcriptional repression by p53 through direct binding to a novel DNA element. J Biol Chem. 2001; 276(29):27716-20.
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