Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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William J. Lane, M.D., Ph.D.

Instructor of Pathology, Harvard Medical School
Director of Clinical Laboratory Informatics; Assistant Director of the Tissue Typing Laboratory

Academic Activities:

60 Fenwood Road
Building for Transformative Medicine (8002L)
Boston,MA 02115
Education and Training:

College 1994 - 1998 : Hofstra University (Hempstead, NY) B.Eng. (Biomechanical Engineering)
Graduate School 2002 - 2007 : The Rockefeller University (New York, NY) PhD (Structural and Computational Biology)
Medical School 2000 - 2009 : Weill Cornell Medical College (New York, NY) MD

Clinical Specialties: Research Interests: Publication:
  1. Opalka N, Brown J, Lane WJ, Twist KA, Landick R, Asturias FJ, Darst SA. Complete structural model of Escherichia coli RNA polymerase from a hybrid approach. PLoS Biol. 2010 Sep 14;8(9). pii: e1000483.
  2. Lane WJ, Darst SA. Molecular Evolution of Multisubunit RNA Polymerases: Structural Analysis. Journal of molecular biology. 2010 Jan 29;395(4):686-704
  3. Lane WJ, Darst SA. Molecular Evolution of Multisubunit RNA Polymerases: Sequence Analysis. Journal of molecular biology. 2010 Jan 29;395(4):671-685
  4. Patikoglou GA, Westblade LF, Campbell EA, Lamour V, Lane WJ, Darst SA. Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4. Journal of molecular biology. 2007 Sep 21;372(3):649-59
  5. Lane WJ, Darst SA. The structural basis for promoter -35 element recognition by the group IV sigma factors. PLoS biology. 2006 Sep;4(9):e269
  6. Shmelkov SV, Meeus S, Moussazadeh N, Kermani P, Rashbaum WK, Rabbany SY, Hanson MA, Lane WJ, St Clair R, Walsh KA, Dias S, Jacobson JT, Hempstead BL, Edelberg JM, Rafii S. Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue. Circulation. 2005 Mar 8;111(9):1175-83
  7. Lane WJ, Hattori K, Dias S, Peerschke EI, Moore MA, Blanset DL, Lang PC, Petrone M, Rafii S. Anagrelide metabolite induces thrombocytopenia in mice by inhibiting megakaryocyte maturation without inducing platelet aggregation. Experimental hematology. 2001 Dec;29(12):1417-24
  8. Lane WJ, Dias S, Hattori K, Heissig B, Choy M, Rabbany SY, Wood J, Moore MA, Rafii S. Stromal-derived factor 1-induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases. Blood. 2000 Dec 15;96(13):4152-9
  9. Rabbany SY, Lane WJ, Marganski WA, Kusterbeck AW, Ligler FS. Trace detection of explosives using a membrane-based displacement immunoassay. Journal of immunological methods. 2000 Dec 1;246(1-2):69-77
  10. Roboz GJ, Dias S, Lam G, Lane WJ, Soignet SL, Warrell RP, Rafii S. Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis. Blood. 2000 Aug 15;96(4):1525-30
  11. Dias S, Hattori K, Zhu Z, Heissig B, Choy M, Lane W, Wu Y, Chadburn A, Hyjek E, Gill M, Hicklin DJ, Witte L, Moore MA, Rafii S. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. The Journal of clinical investigation. 2000 Aug;106(4):511-21
  12. Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L, Moore MA, Rafii S. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood. 2000 Feb 1;95(3):952-8
<June 2019>

<Monday, June 24, 2019>
8:00 AM

Cotran Conference Center
8:00 AM

Autopsy suite
9:00 AM

Clinical Lab conference room
3:00 PM

Dammin signout suite
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