Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
Login Skip Navigation Links
  Skip Navigation Links
HomeExpand Home


Submit new announcement
David Stanley Milstone, M.D.,Ph.D.

Assistant Professor of Pathology, Harvard Medical School

Academic Activities:

75 Francis Street
EBRC 221L-4-421
Boston,MA 02115
Education and Training:

Medical School - : Washington University School of Medicine M.D.
Graduate School - : Washington University School of Medicine Ph.D.
Residency 7/1/85 - 6/19/87 : Brigham and Women's Hospital
Internship 6/20/87 - 12/21/87 : Brigham and Women's Hospital
Fellowship 1/1/88 - 6/30/92 : Harvard Medical School
Professional Position 1/1/74 - : Mit
Professional Position 1/1/76 - 1/1/78 : Sri International

Clinical Specialties: Research Interests:
  • Atherosclerosis
  • Endothelial cell biology
  1. Gerritsen ME, Shen CP, McHugh MC, Atkinson WJ, Kiely JM, Milstone DS, Luscinskas FW, Gimbrone MA. Activation-dependent isolation and culture of murine pulmonary microvascular endothelium. Microcirculation 1995; 2(2):151-163.
  2. Gerritsen ME, Shen CP McHugh MC, Atkinson WJ, Padgett RC, Gimbrone MA Jr, Milstone DS. Microvascular endothelial cells from E-selectin deficient mice form tubes in vitro. Lab Invest 1996; 75(2):175-184.
  3. Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA Jr. Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable adhesion on cytokine-activated dermal microvascular endothelium. Microcirculation 1998; 5:153-171.
  4. Milstone DS, Bradwin G, Mortensen RM. Simultaneous Cre catalyzed recombination of two alleles to restore neomycin sensitivity and facilitate homozygous mutations. Nucleic Acids Res, 1999; 27:e10.
  5. Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. PPAR-g is required for the differentiation of adipose tissue in vivo and in vitro. Molec Cell 1999; 4:611-617
  6. Milstone DS, O'Donnell PE, Stavrakis G, Mortensen RM, Davis VM. E-selectin expression and stimulation by inflammatory mediators are developmentally regulated during embryogenesis. Lab Invest 2000; 80:943-954.
  7. Milstone DS, Redline RW, O'Donnell PE, Davis VM, Stavrakis G. E-selectin expression and function in a unique placental trophoblast population at the fetal-maternal interface: Regulation by a trophoblast-restricted transcriptional mechanism conserved between humans and mice. Dev Dynamics 2000; 219:63-76.
  8. Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Anderson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW. The role of PPARg in macrophage differentiation and cholesterol uptake. Nature Med 2001; 7:41-7.
  9. Cybulsky, MI, Li, H, Chen, M, Iiyama, I, Iiyama, K, Davis, V, Gutierrez-Ramos, J-C and DS. Milstone. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest. 2001;107:1255-62.
  10. Jantzen, H-M, Milstone, DS, Gousset, L, Conley , PB and RM Mortensen. Impaired Activation of Murine Platelets Lacking Gai2. J Clin Invest. 2001;108:477-83.
  11. Milstone, DS, O'Donnell, PE, Davis, VM, Mortensen, RM, and G Stavrakis. PPARg is expressed and regulates placental development and trophoblast differentiation in both humans and mice. The FASEB Journal 2001;15(4):A583.
  12. Vernochet C, Milstone, DS, Iehlé C, Belmonte, N, Phillips B, Wdziekonski, B, Villageois, P, Amri, E.Z, O'Donnell PE, Mortensen RM, Ailhaud, G, and Dani, C. PPARg dependent and PPARg-independent effects on the Development of Adipose Cells from Embryonic Stem Cells. FEBS Letters. 2002; 510:94-8.
<June 2019>

<Monday, June 24, 2019>
8:00 AM

Cotran Conference Center
8:00 AM

Autopsy suite
9:00 AM

Clinical Lab conference room
3:00 PM

Dammin signout suite
Copyright 2008 - 2019, BWH Pathology, All rights reserved.