Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Edmund Saulius Cibas, M.D.

   Associate Professor of Pathology

Director of Cytopathology
Academic Activities:
My research focuses on four principal areas: 1. expanding the scope and improving the accuracy of cytologic examination, particularly with specimens from the uterine cervix, thyroid, cerebrospinal fluid, abdomen, and peripheral blood (e.g., identifying circulating tumor cells with the CellSearch system); 2. applying cytogenetics and molecular cytogenetics to diagnostic cytology; 3. employing informatics for quality improvement and performance evaluation in cytopathology; 4. applying insights from cytology into basic cell biology (e.g., cell “cannibalism” as a clue to the process of entosis, a novel non-apoptotic cell death mechanism).
Office
75 Francis Street
MR-3-310
Boston,MA 02115
Email1: ecibas@partners.org
Education and Training:

Medical School - : Harvard Medical School M.D.
Residency 7/1/82 - 6/30/85 : Brigham and Women's Hospital
Fellowship 7/1/85 - 6/30/86 : Memorial Sloan-Kettering Center

Clinical Specialties:
  • Cytopathology
  • Anatomic Pathology
Research Interests:
  • Cancer
  • Bioinformatics
  • Cell Biology
  • Cell death
  • Targeted therapy
  • Cervical cancer
  • Mesothelioma
  • HPV
Publication:
  1. Cibas ES, Ducatman BS, eds. Cytology: Diagnostic Principles and Clinical Correlates, 2nd ed. Philadelphia: Saunders; 2003.
  2. Alexander EK, Hurwitz S, Heering JP, Benson CB, Frates MC, Doubilet PM, Cibas ES, Larsen PR, Marqusee E. Natural history of benign solid and cystic thyroid nodules. Ann Int Med 2003;138:315-318.
  3. French CA, Alexander EK, Cibas ES, Nose V, Laguette J, Faquin W, Garber J, Moore F, Fletcher JA, Larsen PR, Kroll TG. Genetic and biologic subgroups of early stage follicular thyroid cancer. Am J Pathol 2003;162:1053-1060.
  4. Nasser SM, Cibas ES, Crum CP, Faquin WC. The significance of the Pap smear diagnosis "LSIL cannot exclude HSIL". Cancer (Cancer Cytopathol) 2003; 99:272-6.
  5. Browne T-J, Goumnerova LC, DeGirolami U, Cibas ES. Cytologic features of pilocytic astrocytoma in cerebrospinal fluid specimens. Acta Cytol 2004; 48: 3-8
  6. Alexander EK, Marqusee E, Orcutt J, Benson CB, Frates MC, Doubilet PM, Cibas ES, Atri A. Thyroid nodule shape and prediction of malignancy. Thyroid 2004; 14:953-958.
  7. Matulonis UA, Cibas ES. Positive peritoneal cytology in women with endometrial cancer. In Fuller AF et al. Uterine Cancer. Hamilton (Ontario): BC Decker; 2004.
  8. O'Connell F, Cibas ES. Cytologic features of a ciliated adenocarcinoma of the cervix. Acta Cytol 2005; 49: 187-190.
  9. Faquin WC, Cibas ES, Renshaw AA. Atypical cells in fine needle aspiration specimens of benign thyroid cysts. Cancer (Cancer Cytopathol) 2005; 105: 71-79.
  10. Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, Hay ID, Hertzberg BS, Intenzo CM, Jeffrey RB, Langer JE, Larsen PR, Mandel SJ, Middleton WD, Reading CC, Sherman SI, Tessler FN. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology 2005; 237: 794-800.
  11. Cibas ES, Browne T-J, Bassichis MHM, Lee KR. Enlarged squamous cell nuclei in cervical cytologic specimens from perimenopausal women ("PM cells"): a cause of ASC overdiagnosis. Am J Clin Pathol 2005; 124: 58-61.
  12. Browne T-J, Genest DR, Cibas ES. The clinical significance of benign-appearing endometrial cells on a Pap test in women 40 years of age and older. Am J Clin Pathol 2005; 124: 834-837.
  13. Kindelberger DW, Cibas ES. Evaluating metastatic carcinoma to the adrenal: utility of fine needle aspiration. Pathology Case Reviews 2005; 10: 257-262.
  14. Chang BS, Pinkus G, Cibas ES. Exfoliated endometrial cell clusters are derived from endometrial stroma and glands. Am J Clin Pathol 2006; 125: 77-81.
  15. Silverman SG, Gan YU, Mortele KJ, Tuncali K, Cibas ES. Renal masses in the adult patient: the role of percutaneous biopsy. Radiology 2006; 240:6-22.
  16. Frates MC, Benson CB, Doubilet PM, Kunreuther E, Contreras M, Cibas ES, Orcutt J, Moore FD, Larsen PR, Marqusee E Alexander EK. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endo Metab 2006; 91: 3411-3417.
  17. Cibas, ES, Hong X, Crum CP, Feldman S. Age-specific detection of high risk HPV DNA in cytologically normal, computer-imaged ThinPrep Pap samples. Gynecologic Oncology 2007; 104: 702-706.
  18. Chang BS, Yang T, Cibas ES, Fletcher JA. An in vitro cytologic assay for evaluation of the KIT signaling pathway in gastrointestinal stromal tumors. Mod Pathol 2007; 20: 579-583.
  19. Silverman SG, Mortele KJ, Tuncali K, Jinzaki M, Cibas ES. Hyperattenuating renal masses: etiologies, pathogenesis, and imaging evaluation. RadioGraphics 2007;27:1131-1143.
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