Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Edmund Saulius Cibas, M.D.

Professor of Pathology, Harvard Medical School
Director of Cytopathology
Director of Fine Needle Aspiration
Program Director, Cytopathology Fellowship
Academic Activities:
My research focuses on four principal areas: 1. expanding the scope and improving the accuracy of cytologic examination, particularly with specimens from the uterine cervix, thyroid, cerebrospinal fluid, abdomen, and peripheral blood (e.g., identifying circulating tumor cells with the CellSearch system); 2. applying cytogenetics and molecular cytogenetics to diagnostic cytology; 3. employing informatics for quality improvement and performance evaluation in cytopathology; 4. applying insights from cytology into basic cell biology (e.g., cell “cannibalism” as a clue to the process of entosis, a non-apoptotic cell death mechanism).
75 Francis Street
Boston,MA 02115
Education and Training:

Medical School - : Harvard Medical School M.D.
Residency 7/1/82 - 6/30/85 : Brigham and Women's Hospital
Fellowship 7/1/85 - 6/30/86 : Memorial Sloan-Kettering Center
Fellowship 1994 - : Karolinska Hospital, Stockholm, Sweden

Clinical Specialties:
  • Cytopathology
  • Anatomic Pathology
Research Interests:
  • Cancer
  • Bioinformatics
  • Cell Biology
  • Cell death
  • Targeted therapy
  • Cervical cancer
  • Mesothelioma
  • HPV
  1. Cibas ES, Ducatman BS, eds. Cytology: Diagnostic Principles and Clinical Correlates, 3rd ed. Philadelphia, Elsevier, 2009.
  2. Alexander EK, Hurwitz S, Heering JP, Benson CB, Frates MC, Doubilet PM, Cibas ES, Larsen PR, Marqusee E. Natural history of benign solid and cystic thyroid nodules. Ann Int Med 2003;138:315-318.
  3. French CA, Alexander EK, Cibas ES, Nose V, Laguette J, Faquin W, Garber J, Moore F, Fletcher JA, Larsen PR, Kroll TG. Genetic and biologic subgroups of early stage follicular thyroid cancer. Am J Pathol 2003;162:1053-1060.
  4. Nasser SM, Cibas ES, Crum CP, Faquin WC. The significance of the Pap smear diagnosis "LSIL cannot exclude HSIL". Cancer (Cancer Cytopathol) 2003; 99:272-6.
  5. Browne T-J, Goumnerova LC, DeGirolami U, Cibas ES. Cytologic features of pilocytic astrocytoma in cerebrospinal fluid specimens. Acta Cytol 2004; 48: 3-8
  6. Alexander EK, Marqusee E, Orcutt J, Benson CB, Frates MC, Doubilet PM, Cibas ES, Atri A. Thyroid nodule shape and prediction of malignancy. Thyroid 2004; 14:953-958.
  7. Matulonis UA, Cibas ES. Positive peritoneal cytology in women with endometrial cancer. In Fuller AF et al. Uterine Cancer. Hamilton (Ontario): BC Decker; 2004.
  8. O'Connell F, Cibas ES. Cytologic features of a ciliated adenocarcinoma of the cervix. Acta Cytol 2005; 49: 187-190.
  9. Faquin WC, Cibas ES, Renshaw AA. Atypical cells in fine needle aspiration specimens of benign thyroid cysts. Cancer (Cancer Cytopathol) 2005; 105: 71-79.
  10. Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, Hay ID, Hertzberg BS, Intenzo CM, Jeffrey RB, Langer JE, Larsen PR, Mandel SJ, Middleton WD, Reading CC, Sherman SI, Tessler FN. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology 2005; 237: 794-800.
  11. Cibas ES, Browne T-J, Bassichis MHM, Lee KR. Enlarged squamous cell nuclei in cervical cytologic specimens from perimenopausal women ("PM cells"): a cause of ASC overdiagnosis. Am J Clin Pathol 2005; 124: 58-61.
  12. Browne T-J, Genest DR, Cibas ES. The clinical significance of benign-appearing endometrial cells on a Pap test in women 40 years of age and older. Am J Clin Pathol 2005; 124: 834-837.
  13. Kindelberger DW, Cibas ES. Evaluating metastatic carcinoma to the adrenal: utility of fine needle aspiration. Pathology Case Reviews 2005; 10: 257-262.
  14. Chang BS, Pinkus G, Cibas ES. Exfoliated endometrial cell clusters are derived from endometrial stroma and glands. Am J Clin Pathol 2006; 125: 77-81.
  15. Silverman SG, Gan YU, Mortele KJ, Tuncali K, Cibas ES. Renal masses in the adult patient: the role of percutaneous biopsy. Radiology 2006; 240:6-22.
  16. Frates MC, Benson CB, Doubilet PM, Kunreuther E, Contreras M, Cibas ES, Orcutt J, Moore FD, Larsen PR, Marqusee E Alexander EK. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endo Metab 2006; 91: 3411-3417.
  17. Cibas, ES, Hong X, Crum CP, Feldman S. Age-specific detection of high risk HPV DNA in cytologically normal, computer-imaged ThinPrep Pap samples. Gynecologic Oncology 2007; 104: 702-706.
  18. Chang BS, Yang T, Cibas ES, Fletcher JA. An in vitro cytologic assay for evaluation of the KIT signaling pathway in gastrointestinal stromal tumors. Mod Pathol 2007; 20: 579-583.
  19. Silverman SG, Mortele KJ, Tuncali K, Jinzaki M, Cibas ES. Hyperattenuating renal masses: etiologies, pathogenesis, and imaging evaluation. RadioGraphics 2007;27:1131-1143.
  20. Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS. A non-apoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 2007;131(5):966-79.
  21. Cibas ES, Zou KH, Crum CP, Kuo F. Using the rate of positive high-risk HPV test results for ASC-US together with the ASC-US:SIL ratio in evaluating the performance of the cytopathologist. Am J Clin Pathol 2008;129:97-101.
  22. French CA, Fletcher JA, Cibas ES, Caulifield C, Allard P, Kroll TG. Molecular detection of PPAR? rearrangements and thyroid carcinoma in pre-operative fine needle aspiration biopsies. Endocr Pathol 2008;19:166-174.
  23. Cibas ES, Alexander EK, Benson CB, de Agustin PP, Doherty GM, Faquin WC, Middleton WD, Miller T, Raab SS, White ML, Mandel SJ. Indications for thyroid FNA and pre-FNA requirements: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol 2008;36: 390-399.
  24. Smouse JH, Cibas ES, Janne PA, Joshi VA, Lindeman NI. EGFR mutations are detected comparably in cytologic and surgical pathology specimens of non-small cell lung cancer. Cancer Cytopathology 2009;117:67-72.
  25. Factor RE, Dal Cin P, Fletcher JA, Cibas ES. Cytogenetics and FISH as adjuncts to cytology in the diagnosis of malignant mesothelioma. Cancer (Cancer Cytopathol) 2009; 117: 247-53.
  26. Cibas ES, Ali SZ. The Bethesda System for reporting thyroid cytopathology. Am J Clin Pathol 2009: 132: 658-65.
  27. Cibas ES, Ali SZ. The Bethesda System for reporting thyroid cytopathology. Thyroid 2009: 19: 1159-65.
  28. Roh MH, Dal Cin P, Silverman SG, Cibas ES. The application of cytogenetics and fluorescence in situ hybridization to fine needle aspiration in the diagnosis and subclassification of renal neoplasms. Cancer Cytopathol 2010; 118: 137-45.
  29. Flores LM, Kindelberger DW, Ligon AH, Capelletti M, Florentino M, Loda M, Cibas ES, Janne PA, Krop IE. Improved yields of circulating tumor cells facilitate molecular characterization and recognition of discordant HER2 amplification in breast cancer. Br J Cancer 2010;102(10):1495-502.
  30. Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M. A non-genetic route to aneuploidy in human cancers. Nature Cell Biol 2011; 13: 324-330.
  31. Roh MH*, Jo VY*, Stelow EB, Faquin WC, Zou KH, Alexander EK, Larsen PR, Ellen Marqusee E, Benson CB, Frates MC, Gawande A, Moore FD, Cibas ES. The predictive value of the fine needle aspiration diagnosis “Suspicious for a Follicular Neoplasm, Hürthle Cell Type” in patients with Hashimoto’s thyroiditis. Am J Clin Pathol 2011; 135: 139-45.
  32. Burlingame O, Kesse KO, Silverman S, Cibas ES. On-site adequacy evaluations performed by cytotechnologists: correlation with final cytopathology reports of 5,241 image-guided fine needle aspiration biopsies. Cancer (Cancer Cytopathol) 2012; 120:177-84.
  33. VanderLaan PA, Krane JF, Cibas ES. The frequency of “Atypia of Undetermined Significance” interpretations for thyroid FNAs is negatively correlated with histologically proven malignant outcome. Acta Cytol 2011; 55:512-7.
  34. Alexander EK, Kennedy GC, Baloch ZW, Cibas ES, Chudova D, Diggans J, Friedman L, Kloos RT, LiVolsi VA, Mandel SJ, Raab SS, Rosai J, Steward DL, Walsh PS, Wilde JI, Zeiger MA, Lanman RB, Haugen BR. Diagnosis of benign thyroid nodules with indeterminate FNA cytology. N Engl J Med 2012 June 25 [Epub ahead of print].
<June 2019>

<Monday, June 24, 2019>
8:00 AM

Cotran Conference Center
8:00 AM

Autopsy suite
9:00 AM

Clinical Lab conference room
3:00 PM

Dammin signout suite
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