Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Jon Christopher Aster, M.D.,Ph.D.

Professor of Pathology, Harvard Medical School



Academic Activities:
Notch signaling in leukemia; targeted therapeutics
Office
Room 652 E, NRB
77 Avenue Louis Pasteur
Boston,MA 02115
Email1: jaster@rics.bwh.harvard.edu
Website
Education and Training:

Graduate School 1979 - 1987 : University of Michigan Ph.D.
Medical School - : University of Michigan School of Medicine M.D.
Residency 1987 - 1989 : Brigham and Women's Hospital
Fellowship 1989 - 1990 : Brigham and Women's Hospital

Clinical Specialties:
  • Hematopathology
  • Anatomic Pathology
  • Hematology
Research Interests:
  • Leukemia
  • Lymphoma
  • Cell fate decision
  • Oncogenesis
  • Signalling pathway
  • Chromosomal translocation
Publication:
  1. Aster JC, Xu L, Karnell FG, Patriub V, Pui JC, Pear WS. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1. Mol Cell Biol 2000; 20:7505-7515.
  2. Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 2000; 26:484-489.
  3. Shipp MA, Tamayo P, Ross K, Weng AP, Kutok JL, Aguiar RCT, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov, Neuberg DS, Lander ES, Aster JC, Golub TR. Diffuse large B-cell lymphoma outcome prediction by gene expression profiling and supervised machine learning. Nat Med 2002:8;68-74.
  4. Izon DJ*, Aster JC*, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriquez R, Allman D, Pear WS. Deltex1 promotes B cell development at the expense of T cell development by antagonizing Notch1. Immunity 2002:16;1-20.
  5. Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of Notch signaling. Mol Cell Biol 2003:23;655-64.
  6. Griffin JD, Blacklow SC, Aster JC. Growth suppression of pre-T acute
  7. Weng AP, Ferrando AA, Lee W, Morris IV JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in T cell acute lymphoblastic leukemia. Science 2004:306;269-71.
  8. Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC. NOTCH subunit heterodimerization and prevention of ligand-independent proteolytic activation depend respectively on a novel domain and the LNR repeats. Mol Cell Biol 2004:24;9265-73.
  9. Santagata S, Francesca D, Riva A, Varambally S, Hofer MD, Kutok JL, Kim R, Tang J, Montie JE, Chinnaiyan AM, Rubin MA, Aster JC. JAGGED1 is upregulated in metastatic prostate cancer and is associated with prostate cancer recurrence. Cancer Res 2004:64;6854-7.
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