Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Jason L. Hornick, M.D.,Ph.D.

Associate Professor of Pathology, Harvard Medical School
Director of Surgical Pathology
Director, Immunohistochemistry Laboratory

Academic Activities:
Soft tissue tumors, gastrointestinal pathology, immunohistochemistry
75 Francis Street
Amory AL.360D
Boston,MA 02115
Education and Training:

Medical School 1991 - 1999 : University of Southern California Keck School of Medicine M.D., Ph.D.
Residency 1999 - 2002 : Brigham and Women's Hospital
Fellowship 2002 - 2003 : Brigham and Women's Hospital

Clinical Specialties:
  • Molecular Genetics
  • Anatomic Pathology
  • Soft tissue and bone Pathology
  • Hematopathology
  • Gastrointestinal Pathology
Research Interests: Publication:
  1. Hornick JL, Fletcher CDM. Immunohistochemical staining for KIT (CD117) in soft tissue sarcomas is very limited in distribution. Am J Clin Pathol 2002;117:188-93.
  2. Hornick JL, Fletcher CDM. Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters. Am J Surg Pathol 2003;27:1183-96.
  3. Odze RD, Farraye FA, Hecht JL, Hornick JL. Long-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitis. Clin Gastro Hepatol 2004;2:534-41.
  4. Hornick JL, Jaffe ES, Fletcher CDM. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol 2004;28:1133-44.
  5. Hornick JL, Bosenberg MW, Mentzel T, McMenamin ME, Oliveira AM, Fletcher CDM. Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. Am J Surg Pathol 2004;28:1257-67.
  6. Hornick JL, Blount PL, Sanchez CA, Cowan DS, Ayub K, Maley CC, Reid BJ, Odze RD. Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagus. Am J Surg Pathol 2005;29:372-80.
  7. Hornick JL, Lauwers GY, Odze RD. Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. Am J Surg Pathol 2005;29:381-9.
  8. Hornick JL, Fletcher CDM. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol 2005;29:845-58.
  9. Hornick JL, Farraye FA, Odze RD. Prevalence and significance of prominent mucin pools in the esophagus post neoadjuvant chemoradiotherapy for Barrett's-associated adenocarcinoma. Am J Surg Pathol 2006;30:28-35.
  10. Hornick JL, Fletcher CDM. PEComa: what do we know so far? Histopathology 2006;48:75-82.
  11. Coffin CM, Hornick JL, Zhou H, Fletcher CDM. Gardner fibroma: a clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas. Am J Surg Pathol 2007;31:410-6.
  12. Hornick JL, Fletcher CDM. Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol 2007;31:329-40
  13. Srivastava A, Hornick JL, Li X, Blount PL, Sanchez CA, Cowan DS, Ayub K, Maley CC, Reid BJ, Odze RD. Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus. Am J Gastroenterol 2007;102:483-93.
  14. Coffin CM, Hornick JL, Fletcher CDM. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features and ALK expression in atypical and aggressive cases. Am J Surg Pathol 2007;31:509-20.
  15. Hornick JL, Fletcher CDM. The role of KIT in the management of patients with gastrointestinal stromal tumors. Hum Pathol 2007;38:679-87.
  16. Santagata S, Ligon KL, Hornick JL. Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors. Am J Surg Pathol 2007;31:836-45.
  17. Hahn HP, Hornick JL. Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis. Am J Surg Pathol 2007;31:1669-76.
  18. Yu H, Gibson JA, Pinkus GS, Hornick JL. Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors. Am J Clin Pathol 2007;128:776-82.
  19. Gleason B, Hornick JL. Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol 2008;61:428-37.
  20. Hollmann TJ, Brenn T, Hornick JL. CD25 expression on cutaneous mast cells from adult patients presenting with urticaria pigmentosa is predictive of systemic mastocytosis. Am J Surg Pathol 2008;32:139-45.
  21. Hornick JL, Mino-Kenudson M, Lauwers GY, Liu W, Goyal R, Odze RD. Buried Barrett's epithelium following photodynamic therapy shows reduced crypt proliferation and absence of DNA content abnormalities. Am J Gastroenterol 2008;103:38-47.
  22. Hornick JL, Fletcher CDM. Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum. Am J Surg Pathol 2008;32:493-501.
  23. Liegl B, Hornick JL, Fletcher CDM. Primary cutaneous PEComa: distinctive clear cell lesions of skin. Am J Surg Pathol 2008;32:608-14.
  24. Cho NL, Redston M, Zauber AG, Carothers AM, Hornick J, Wilton A, Sontag S, Nishioka N, Giardiello FM, Saltzman JR, Gostout C, Eagle CJ, Hawk ET, Bertagnolli MM. Aberrant crypt foci in the Adenoma Prevention with Celecoxib trial. Cancer Prev Res 2008;1:21-31.
  25. Gasparotto D, Rossi S, Bearzi I, Doglioni C, Marzotto A, Hornick JL, Grizzo A, Sartor C, Moldolesi A, Sciot R, Debiec-Rychter M, Dei Tos AP, Maestro R. Multiple primary sporadic gastrointestinal stromal tumors (GIST) in the adult: an underestimated entity. Clin Cancer Res 2008;14: 5715-21.
  26. Wang VS, Hornick JL, Sepulveda JA, Mauer R, Poneros JM. Low prevalence of submucosal invasive carcinoma at esophagectomy for high-grade dysplasia or intramucosal adenocarcinoma in Barrett's esophagus: a 20 year experience. Gastrointest Endosc 2009;69:777-83.
  27. Gleason B, Hornick JL. Myoepithelial tumours of skin and soft tissue: an update. Diagn Histopathol 2008;14:552-62.
  28. Liegl B, Hornick JL, Antonescu CR, Corless CL, Fletcher CDM. Rhabdomyosarcomatous differentiation in gastrointestinal stromal tumors after tyrosine kinase inhibitor therapy: a novel form of tumor progression. Am J Surg Pathol 2009;33:218-26.
  29. Liegl B, Hornick JL, Corless CL, Fletcher CDM. Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes. Am J Surg Pathol 2009;33:437-46.
  30. Kulke MH, Hornick JL, Frauenhoffer C, Hooshmand S, Ryan DP, Enzinger PC, Meyerhardt JA, Clark JW, Stuart K, Fuchs CS, Redston MS. O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors. Clin Cancer Res 2009;15: 338-45.
  31. Yang Q, Hornick JL, Granter SR, Wang LC. Merkel cell carcinoma: lack of KIT positivity and implications for the use of imatinib mesylate. Appl Immunohistochem Mol Morphol 2009;17:276-81.
  32. Hornick JL, Dal Cin P, Fletcher CDM. Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Am J Surg Pathol 2009;33:542-50.
  33. Srivastava A, Hornick JL. Immunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumors from pancreatic endocrine and pulmonary carcinoid tumors. Am J Surg Pathol 2009;33:626-32.
  34. Gibson JA, Hornick JL. Mucosal Schwann cell "hamartoma": clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas. Am J Surg Pathol 2009;33:781-7.
  35. Brock JE, Hornick JL, Richardson A, Dillon D, Lester SC. A comparison of estrogen receptor SP1 and 1D5 monoclonal antibodies in routine clinical use reveals similar staining results. Am J Clin Pathol 2009;132:396-401.
  36. Boland JM, Folpe AL, Hornick JL, Grogg KL. Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. Am J Surg Pathol 2009;33:1225-9.
  37. Baba Y, Nosho K, Shima K, Freed E, Irahara N, Philips J, Meyerhardt JA, Hornick JL, Shivdasani RA, Fuchs CS, Ogino S. Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer: implications for clinical and pathology practice. Clin Cancer Res 2009;15:4665-73.
  38. Hornick JL, Bundock EA, Fletcher CDM. Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol 2009;33:1554-61.
  39. Long KB, Hornick JL. SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract. Hum Pathol 2009;40:1768-73.
  40. Coco D, Hirsch MS, Hornick JL. Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract. Am J Surg Pathol 2009;33:1795-1801.
  41. Liegl B, Hornick JL, Lazar AJF. Contemporary pathology of gastrointestinal stromal tumors. Hematol Oncol Clin North Am 2009;23:49-68.
  42. Sholl LM, Long KB, Hornick JL. SOX2 expression in pulmonary non-small cell and neuroendocrine carcinomas. Appl Immunohistochem Mol Morphol 2010;18:55–61.
  43. Laury AR, Hornick JL, Perets R, Corson J, Drapkin R, Hirsch MS. PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma. Am J Surg Pathol 2010, in press.
  44. Mino-Kenudson M, Chirieac LR, Law K, Hornick JL, Lindeman N, Mark EJ, Cohen DW, Johnson BE, Jänne PA, Iafrate AJ, Rodig SJ. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res 2010;16:1561-1571.
  45. Long KB, Srivastava A, Hirsch MS, Hornick JL. PAX8 expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors. Am J Surg Pathol 2010, in press.
  46. Long KB, Butrynski JE, Blank SD, Ebrahim KS, Dressel DM, Heinrich MC, Corless CL, Hornick JL. Primary extra-gastrointestinal stromal tumor of the pleura: report of a unique case with genetic confirmation. Am J Surg Pathol 2010, in press.
  47. Hornick JL. Myofibroblastic tumors in children. Surg Pathol Clin North Am 2010, in press.
<September 2019>

<Sunday, September 15, 2019>
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