Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Lynette Marie Sholl, M.D.

Assistant Professor, Harvard Medical School



Academic Activities:
Molecular mechanisms of pulmonary tumorigenesis and interstitial lung disease
Office
75 Francis Street
AL3-107 Amory Building
Boston,MA 02115
Email1: lmsholl@partners.org
Education and Training:

Medical School - : Stanford University School of Medicine M.D
Internship 06/2003 - 06/2004 : Hospital of the University of Pennsylvania internship
Residency 2004 - 2008 : Brigham and Women's Hospital
Fellowship 2006 - 2007 : Molecular Genetic Pathology
Fellowship 2008 - 2009 : Brigham and Women's Hospital Corson Thoracic Pathology Fellowship

Clinical Specialties:
  • Anatomic Pathology
  • Molecular Diagnostics
  • Pulmonary Pathology
Research Interests:
  • Lung Cancer
  • Transplant pathology
  • miRNA
  • Immunohistochemistry
Publication:
  1. Trujillo G, Meneghin A, Flaherty KR, Sholl LM, Myers JL, Kazerooni EA, Gross BH, Oak SR, Coelho AL, Evanoff H, Day E, Toews GB, Joshi AD, Schaller MA, Waters B, Jarai G, Westwick J, Kunkel SL, Martinez FJ, Hogaboam CM.TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis. Sci Transl Med. 2010 Nov 10;2(57):57ra82.
  2. Sholl LM, Longtine J. Molecular analysis of gene rearrangements and mutations in acute leukemias and myeloproliferative neoplasms. Curr Protoc Hum Genet. 2010 Oct;Chapter 10:Unit 10.4
  3. Sholl LM, Barletta JA, Yeap BY, Chirieac LR, Hornick JL.Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma. Am J Surg Pathol. 2010 Aug;34(8):1193-8.
  4. Sholl LM, Longtine J. Molecular analysis of genetic markers for non-Hodgkin lymphomas. Curr Protoc Hum Genet. 2010 Apr;Chapter 10:Unit 10.14.1-25.
  5. Sholl LM, Yeap BY, Iafrate AJ, Holmes-Tisch AJ, Chou YP, Wu MT, Goan YG, Su L, Benedettini E, Yu J, Loda M, Jänne PA, Christiani DC, Chirieac LR. 2009. Lung adenocarcinoma with EGFR amplification has distinct clinicopathologic and molecular features in never-smokers. Cancer Res. 69:8341-8.
  6. Sholl LM, Long KB and Hornick JL. 2010. Sox2 expression in non small cell and pulmonary neuroendocrine carcinomas. Appl Immunohistochem Mol Morphol. 18:55-61.
  7. Sholl, L.M., John Iafrate, A., Chou, Y.P., Wu, M.T., Goan, Y.G., Su, L., Huang, Y.T., Christiani, D.C., and Chirieac, L.R. 2007. Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma. Mod Pathol 20:1028-1035.
  8. Sholl, L.M., Hornick, J.L., Pinkus, J.L., Pinkus, G.S., and Padera, R.F. 2007. Immunohistochemical analysis of langerin in langerhans cell histiocytosis and pulmonary inflammatory and infectious diseases. Am J Surg Pathol 31:947-952.
  9. Sood R, Sholl L, Isermann B, Zogg M, Coughlin, SR, Weiler, H. Maternal Platelets And Par4 Contribute To Defective Placenta Formation In Mouse Embryos Lacking Thrombomodulin. Blood. 2008 Aug 1;112(3):585-91.
  10. Wu, D., Vu, Q., Nguyen, A., Stone, J.R., Stubbs, H., Kuhlmann, G., Sholl, L.M., and Iafrate, A.J. 2009. In situ genetic analysis of cellular chimerism. Nat Med 15:215-219.
  11. Yu, J., Kane, S., Wu, J., Benedettini, E., Li, D., Reeves, C., Innocenti, G., Wetzel, R., Crosby, K., Becker, A., Ferrante, M., Cheung, W.C., Hong, X., Chirieac, L.R., Sholl, L.M., Haack, H., Smith, B.L., Polakiewicz, R.D., Tan, Y., Gu, T.L., Loda, M., Zhou, X., Comb, M.J. 2009. Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer. Clin Cancer Res. 15:3023-8.
  12. Keen J, Sholl L, Wills-Karp M, and Georas S. Preferential Activation of Nuclear Factor of Activated T Cells Correlates with Mouse Strain Susceptibility to Allergic Responses and Interleukin-4 Gene Expression. American Journal of Respiratory Cell and Molecular Biology. 2001; 24: 58-65.
  13. Abel, G.A., DeAngelo, D.J., Connors, J.M., Sholl, L.M., McCaffrey, R.P., and Longtine, J.A. 2008. Clinical JAK2V617F mutation testing: Limited utility for general hospital patients with venous and arterial thromboses in common locations. Am J Hematol 83:519-520.
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