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Paola Dal Cin, Ph.D.
Associate Professor of Pathology
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Academic Activities:
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LAb
75 Francis Street
CAMD , SHAPIRO 5
Boston,MA
02115
Email1:
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Office
75 Francis Street
CAMD, SHAPIRO 5-058
Boston,MA
02115
Email1:
pdalcin@partners.org
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Education and Training:
Unknown
7/1/86
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6/30/87
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Roswell Park Memorial Institute, Dept of Genetics
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Unknown
7/1/87
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6/30/88
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The Cancer Center Of The Southwest Biomedical Research Institute
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Professional Position
7/1/88
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12/31/98
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Center for Human Genetics, University of Leuven, Belgium
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Clinical Specialties:
Research Interests:
- Chromosomal translocation
- Genetic alteration
- Leukemia
- Lymphoma
- Sarcoma
- Cancer
Publication:
- Pentimalli F, Dentice M, Fedele M, Pierantoni GM, Francesco Trapasso F, Cito L , Santoro M, Viglietto G, Dal Cin P, Fusco A. Suppression of HMGA2 protein synthesis could be a tool for therapy of well-differentiated liposarcoma overexpressing HMGA2. Cancer Res 2003; 63(21):7423-7.
- Dal Cin P, Thomas A, Weremowicz S. An intragenic rearrangement of HMGA2 is not necessary to occur for lipoma formation. Cancer Genet Cytogenet 2004, 149; 178-179.
- Oliveira AM, Hsi BL, Weremowicz S, Perez-Atayde AR, Rosenberg AE, Dal Cin P, Bridge JA, Fletcher JA. USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. Cancer Res, 2004, 64:1920-1923.
- Moore SDP, Herrick SR, Ince TA, Kleinman MS, Dal Cin P, Morton CC, Quade BJ. Uterine leiomyoma with t(10;17) disrupt the histone acetyltransferase MORF. Cancer Res 2004, 64: 5570-5577.
- Monti S, Savage KJ, Kutok JL, Feuerhake F, Kurtin P, Mihm M, Bingyan Wu B, Pasqualucci L, Neuberg D, Aguiar RCT, Dal Cin P, Ladd C, Pinkus GS, Salles G, Harris NL, Dalla-Favera R, Habermann TM, Aster JC, Golub TR, Shipp MA. Molecular profiling of diffuse large B-cell lymphoma reveals discrete clusters including one characterized by host inflammatory response. Blood 2005, 105:1851-61.
- Oliveira AM, Perez-Atayde AR, Dal Cin P, Gebhardt MC, Rosenberg AE, Bridge JA, Fletcher JA.. Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150 and OMD genes. Oncogene 2005, 24: 3419-3426.
- Christacos NC, Quade BJ, Morton CC, Dal Cin P. Uterine leiomyomata with deletions of 1p represent a distinct cytogenetic subgroup associated with unusual histologic features. Genes Chromosomes Cancer, 2006,45:304-312.
- Antonescu CR, Nafa K , Segal, NH , Dal Cin P, Ladanyi M. WS-CREB1: A recurrent variant fusion in clear cell sarcoma Association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res, 2006,12:5356-5362
- Nucci MR, Harburger D, Koontz J, Dal Cin P, Sklar J. Molecular analysis of the JAZF1/JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am J Surg Path; 2007, 31:65-70
- Soupir CP, Vergilio JA, Dal Cin P, Muzikansky A, Jones DM, Kantarjian H, Hasserjian RP. Philadelphia chromosome positive acute myeloid leukemia: A rare aggressive leukemia with distinct clinicopathologic features from chronic myeloid leukemia in blast crisis. Am J Clin Path 2007, 127:642-650.
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