Department of Pathology
  Brigham and Women's Hospital
  A teaching Affliate of Harvard Medical School
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Paola Dal Cin, Ph.D.

Associate Professor of Pathology, Harvard Medical School

Academic Activities:

75 Francis Street
Boston,MA 02115
75 Francis Street
Boston,MA 02115
Education and Training:

College 1967 - 1972 : Scientific School Vittorio Veneto. Teviso, Italy. B.S.
Graduate School 1972 - 1977 : University of Padua, Italy. M.S. Biology
Graduate School 1982 - 1986 : University of Pavia, Italy. Ph.D. Genetics
Professional Position 1986 - 1987 : Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, NY. Cancer Research Scientist
Professional Position 1987 - 1988 : The Cancer Center of the Southwest Biomedical Research Institute, Scottsdale, AZ. Research Associate

Clinical Specialties:
  • Cytogenetics
Research Interests:
  • Chromosomal translocation
  • Genetic alteration
  • Leukemia
  • Lymphoma
  • Sarcoma
  • Cancer
  1. Christacos NC, Quade BJ, Morton CC, Dal Cin P. Uterine leiomyomata with deletions of 1p represent a distinct cytogenetic subgroup associated with unusual histologic features. Genes Chromosomes Cancer, 2006,45:304-312.
  2. Antonescu CR, Nafa K , Segal, NH , Dal Cin P, Ladanyi M. WS-CREB1: A recurrent variant fusion in clear cell sarcoma Association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res, 2006,12:5356-5362
  3. Nucci MR, Harburger D, Koontz J, Dal Cin P, Sklar J. Molecular analysis of the JAZF1/JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am J Surg Path 2007; 31:65-70.
  4. Soupir CP, Vergilio JA, Dal Cin P, Muzikansky A, Jones DM, Kantarjian H, Hasserjian RP. Philadelphia chromosome positive acute myeloid leukemia: a rare aggressive leukemia with distinct clinicopathologic features from chronic myeloid leukemia in blast crisis. Am J Clin Path 2007; 127:642-650.
  5. Takeyama K, Monti S, Manis JP, Dal Cin P, Getz G, Beroukhim R, Aster JC, Alt FW, Golub TR, Shipp MA. Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphoma. Oncogene 2008; 27: 318-322.
  6. Mertz KD, Demichelis F, Sboner A, Hirsch MS, Dal Cin P, Struckmann K, Storz M, Scherrer S, Schmid DM, Probst-Hensch NM, Gerstein M, Moch H, Rubin MA. Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer. Int J Cancer 2008; 123: 569-576.
  7. Soupir CP, Vergilio J-A, Kelly E, Dal Cin P, Kuter D, Hasserjian RP. Identification of del(20q) in a subset of patients diagnosed with idiopathic thrombocytopenic purpura. Br J Hem 2009;144: 800-802.
  8. Sumegi J, Streblow R, Frayer RW, Dal Cin P, Rosenberg A, Meloni-Ehrig A, Bridge JA. Recurrent (2;2) and (2;8) translocations in Rhabdomyosarcoma without the canonical PAX-FOXO1 fuse PAX3 to members of the nuclear receptor transcriptional coactivator (NCOA) family. Genes Chromosomes Cancer 2010; 49:224-236.
  9. Factor RE, Dal Cin P, Fletcher JA, Cibas ED. Cytogenetics and FISH as adjuncts to cytology in the diagnosis of malignant mesothelioma. Cancer Cytopathol 2009; 117:247-253.
  10. Yoda A, Yoda Y, Chiaretti S, Mani K, Rodig S, Brown J, Mitsiades CS, Sattler M, Kutok J, DeAngelo D, Wadleigh M, Stone R, Xiao Y, Dal Cin P, Piciocchi A, Griffin J, Anderson K, Ritz J, Foa R, Aster J, Weinstock D. Functional oncogene screening identifies CRLF2 in B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2010; 107: 252-257.
  11. Snuderl M, Kolman OK, Chen Y-B, Hsu JJ, Ackerman AM, Dal Cin P, Ferry JA, Harris NL, Hasserjian RP, Zukerberg LR, Abramson JS, Hochberg EP, Lee H, Lee AI, Toomey CE, Sohani AR. B-cell Lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma. Am J Surg Path 2010; 34:327-340.
<September 2019>

<Sunday, September 15, 2019>
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